Soluble CD14 Subtype in Peripheral Blood is a Biomarker for Early Diagnosis of Sepsis

Abstract Objective To study the value of serum soluble CD14 subtype (sCD14-ST) in early diagnosis of sepsis. Methods Seventy-two patients were diagnosed with systemic inflammatory response syndrome, sepsis, or septic shock. Peripheral blood was collected at 0, 12, 24, and 48 hours after admission to...

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Published in:Laboratory medicine 2020-11, Vol.51 (6), p.614-619
Main Authors: Zhou, Wuqiong, Rao, Heping, Ding, Qiuming, Lou, Xiang, Shen, Jianjiang, Ye, Bin, Xiang, Caixia
Format: Article
Language:English
Subjects:
Analysis
Biomarkers
C-reactive protein
Ethylenediaminetetraacetic acid
Health aspects
Infection
Medical diagnosis
Sepsis
Septic shock
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cited_by cdi_FETCH-LOGICAL-c354t-d21490a7efe8e75ca1608c3f9c2b7d5f1c7804f2c44c7eecdcae9457c7abf3c43
cites cdi_FETCH-LOGICAL-c354t-d21490a7efe8e75ca1608c3f9c2b7d5f1c7804f2c44c7eecdcae9457c7abf3c43
container_end_page 619
container_issue 6
container_start_page 614
container_title Laboratory medicine
container_volume 51
creator Zhou, Wuqiong
Rao, Heping
Ding, Qiuming
Lou, Xiang
Shen, Jianjiang
Ye, Bin
Xiang, Caixia
description Abstract Objective To study the value of serum soluble CD14 subtype (sCD14-ST) in early diagnosis of sepsis. Methods Seventy-two patients were diagnosed with systemic inflammatory response syndrome, sepsis, or septic shock. Peripheral blood was collected at 0, 12, 24, and 48 hours after admission to the hospital. Levels of sCD14-ST, procalcitonin (PCT), hypersensitive C-reactive protein (CRP), and white blood cells (WBC) were determined. Results Levels of sCD14-ST in the patients with septic shock were higher than those in the other patients (P < .01) and peaked at 48 h. PCT and CRP levels were similar in the patients at admission but increased by 5 times to 10 times in the next 48 h, especially in the patients with septic shock. WBC levels remained high and did not change dramatically. Receiver operating characteristic analysis revealed that the area under the curve, sensitivity, and specificity values of sCD14-ST to diagnose sepsis were much higher than those of the other markers. Conclusion Compared with PCT, CRP, and WBC, sCD14-ST is a better biomarker for the early diagnosis of sepsis.
doi_str_mv 10.1093/labmed/lmaa015
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Methods Seventy-two patients were diagnosed with systemic inflammatory response syndrome, sepsis, or septic shock. Peripheral blood was collected at 0, 12, 24, and 48 hours after admission to the hospital. Levels of sCD14-ST, procalcitonin (PCT), hypersensitive C-reactive protein (CRP), and white blood cells (WBC) were determined. Results Levels of sCD14-ST in the patients with septic shock were higher than those in the other patients (P &lt; .01) and peaked at 48 h. PCT and CRP levels were similar in the patients at admission but increased by 5 times to 10 times in the next 48 h, especially in the patients with septic shock. WBC levels remained high and did not change dramatically. Receiver operating characteristic analysis revealed that the area under the curve, sensitivity, and specificity values of sCD14-ST to diagnose sepsis were much higher than those of the other markers. Conclusion Compared with PCT, CRP, and WBC, sCD14-ST is a better biomarker for the early diagnosis of sepsis.</description><identifier>ISSN: 0007-5027</identifier><identifier>EISSN: 1943-7730</identifier><identifier>DOI: 10.1093/labmed/lmaa015</identifier><identifier>PMID: 32382753</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Analysis ; Biomarkers ; C-reactive protein ; Ethylenediaminetetraacetic acid ; Health aspects ; Infection ; Medical diagnosis ; Sepsis ; Septic shock</subject><ispartof>Laboratory medicine, 2020-11, Vol.51 (6), p.614-619</ispartof><rights>American Society for Clinical Pathology 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2020</rights><rights>American Society for Clinical Pathology 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>COPYRIGHT 2020 Oxford University Press</rights><rights>American Society for Clinical Pathology 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-d21490a7efe8e75ca1608c3f9c2b7d5f1c7804f2c44c7eecdcae9457c7abf3c43</citedby><cites>FETCH-LOGICAL-c354t-d21490a7efe8e75ca1608c3f9c2b7d5f1c7804f2c44c7eecdcae9457c7abf3c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32382753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Wuqiong</creatorcontrib><creatorcontrib>Rao, Heping</creatorcontrib><creatorcontrib>Ding, Qiuming</creatorcontrib><creatorcontrib>Lou, Xiang</creatorcontrib><creatorcontrib>Shen, Jianjiang</creatorcontrib><creatorcontrib>Ye, Bin</creatorcontrib><creatorcontrib>Xiang, Caixia</creatorcontrib><title>Soluble CD14 Subtype in Peripheral Blood is a Biomarker for Early Diagnosis of Sepsis</title><title>Laboratory medicine</title><addtitle>Lab Med</addtitle><description>Abstract Objective To study the value of serum soluble CD14 subtype (sCD14-ST) in early diagnosis of sepsis. Methods Seventy-two patients were diagnosed with systemic inflammatory response syndrome, sepsis, or septic shock. Peripheral blood was collected at 0, 12, 24, and 48 hours after admission to the hospital. Levels of sCD14-ST, procalcitonin (PCT), hypersensitive C-reactive protein (CRP), and white blood cells (WBC) were determined. Results Levels of sCD14-ST in the patients with septic shock were higher than those in the other patients (P &lt; .01) and peaked at 48 h. PCT and CRP levels were similar in the patients at admission but increased by 5 times to 10 times in the next 48 h, especially in the patients with septic shock. WBC levels remained high and did not change dramatically. Receiver operating characteristic analysis revealed that the area under the curve, sensitivity, and specificity values of sCD14-ST to diagnose sepsis were much higher than those of the other markers. 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Methods Seventy-two patients were diagnosed with systemic inflammatory response syndrome, sepsis, or septic shock. Peripheral blood was collected at 0, 12, 24, and 48 hours after admission to the hospital. Levels of sCD14-ST, procalcitonin (PCT), hypersensitive C-reactive protein (CRP), and white blood cells (WBC) were determined. Results Levels of sCD14-ST in the patients with septic shock were higher than those in the other patients (P &lt; .01) and peaked at 48 h. PCT and CRP levels were similar in the patients at admission but increased by 5 times to 10 times in the next 48 h, especially in the patients with septic shock. WBC levels remained high and did not change dramatically. Receiver operating characteristic analysis revealed that the area under the curve, sensitivity, and specificity values of sCD14-ST to diagnose sepsis were much higher than those of the other markers. 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subjects Analysis
Biomarkers
C-reactive protein
Ethylenediaminetetraacetic acid
Health aspects
Infection
Medical diagnosis
Sepsis
Septic shock
title Soluble CD14 Subtype in Peripheral Blood is a Biomarker for Early Diagnosis of Sepsis
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