Rh(I)-Catalyzed C6-Selective Decarbonylative Alkylation of 2-Pyridones with Alkyl Carboxylic Acids and Anhydrides

A Rh-catalyzed chelation-assisted C6-selective C-H activation/alkylation of 2-pyridones with readily available alkyl carboxylic acids or anhydrides is introduced. The reaction proceeds via substrate decarbonylation. This approach merges C-H functionalization with readily available anhydrides, allowi...

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Bibliographic Details
Published in:Organic letters 2020-06, Vol.22 (11), p.4228-4234
Main Authors: Zhao, Haoqiang, Xu, Xin, Yu, Haiyang, Li, Bohan, Xu, Xingyu, Li, Huanrong, Xu, Lijin, Fan, Qinghua, Walsh, Patrick J
Format: Article
Language:English
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Summary:A Rh-catalyzed chelation-assisted C6-selective C-H activation/alkylation of 2-pyridones with readily available alkyl carboxylic acids or anhydrides is introduced. The reaction proceeds via substrate decarbonylation. This approach merges C-H functionalization with readily available anhydrides, allowing for the efficient synthesis of various C6-alkylated 2-pyridones with good functional group tolerance.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c01277