Rh(I)-Catalyzed C6-Selective Decarbonylative Alkylation of 2-Pyridones with Alkyl Carboxylic Acids and Anhydrides

A Rh-catalyzed chelation-assisted C6-selective C-H activation/alkylation of 2-pyridones with readily available alkyl carboxylic acids or anhydrides is introduced. The reaction proceeds via substrate decarbonylation. This approach merges C-H functionalization with readily available anhydrides, allowi...

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Published in:Organic letters 2020-06, Vol.22 (11), p.4228-4234
Main Authors: Zhao, Haoqiang, Xu, Xin, Yu, Haiyang, Li, Bohan, Xu, Xingyu, Li, Huanrong, Xu, Lijin, Fan, Qinghua, Walsh, Patrick J
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cited_by cdi_FETCH-LOGICAL-c305t-30a74c700c90c545f104b9ffca1170afac84e4983bf0ed378e814e418be41c1a3
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container_end_page 4234
container_issue 11
container_start_page 4228
container_title Organic letters
container_volume 22
creator Zhao, Haoqiang
Xu, Xin
Yu, Haiyang
Li, Bohan
Xu, Xingyu
Li, Huanrong
Xu, Lijin
Fan, Qinghua
Walsh, Patrick J
description A Rh-catalyzed chelation-assisted C6-selective C-H activation/alkylation of 2-pyridones with readily available alkyl carboxylic acids or anhydrides is introduced. The reaction proceeds via substrate decarbonylation. This approach merges C-H functionalization with readily available anhydrides, allowing for the efficient synthesis of various C6-alkylated 2-pyridones with good functional group tolerance.
doi_str_mv 10.1021/acs.orglett.0c01277
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title Rh(I)-Catalyzed C6-Selective Decarbonylative Alkylation of 2-Pyridones with Alkyl Carboxylic Acids and Anhydrides
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