Factors associated with serum progesterone concentrations the day before cryopreserved embryo transfer in artificial cycles

What factors determine serum progesterone concentrations the day before cryopreserved embryo transfer in artificially prepared cycles? Retrospective cohort study at a university-affiliated fertility centre including infertile women under 45 years old using own oocytes who underwent a total of 685 si...

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Bibliographic Details
Published in:Reproductive biomedicine online 2020-06, Vol.40 (6), p.797-804
Main Authors: González-Foruria, Iñaki, Gaggiotti-Marre, Sofia, Álvarez, Manuel, Martínez, Francisca, García, Sandra, Rodríguez, Ignacio, Coroleu, Buenaventura, Polyzos, Nikolaos P.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Artificial preparation
Birth Rate
Body Weight - physiology
Cryopreservation
Embryo Transfer - methods
Female
Frozen embryo transfer
Hormone replacement therapy
Humans
Infertility, Female - blood
Infertility, Female - therapy
Live Birth
Live birth rate
Ovulation Induction
Pregnancy
Pregnancy Rate
Progesterone
Progesterone - blood
Retrospective Studies
Time Factors
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Summary:What factors determine serum progesterone concentrations the day before cryopreserved embryo transfer in artificially prepared cycles? Retrospective cohort study at a university-affiliated fertility centre including infertile women under 45 years old using own oocytes who underwent a total of 685 single cryopreserved blastocyst transfers under hormonal therapy. Determinants that affected live birth rate (LBR) were analysed using a multivariate logistic regression. Univariate analysis and multivariate linear regression were used to evaluate independent factors that affect serum progesterone concentrations. Age (odds ratio [OR] 0.93; 95% confidence interval [CI] 0.89–0.96), duration of oestradiol (OR 0.96; 95% CI 0.92–0.99), serum progesterone concentrations (OR 1.04; 95% CI 1.01–1.08) and patients who underwent preimplantation genetic testing for aneuploidies (PGT-A) (OR 2.17; 95% CI 1.55–3.03) were independently associated with LBR. After univariate analysis, determinants of progesterone concentrations were: age, weight, history of a previous cryopreserved embryo transfer with serum progesterone concentrations
ISSN:1472-6483
1472-6491
DOI:10.1016/j.rbmo.2020.03.001