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Memory and Executive Dysfunction Predict Complex Activities of Daily Living Impairment in Amnestic Multi-Domain Mild Cognitive Impairment
Background: Specific cognitive alterations could be one of the predictors that lead to the complex activities of daily living (CADL) impairment in mild cognitive impairment (MCI) and, hence, help to explain the continuum between MCI and dementia. Objective: We aimed to reevaluate the existing uncert...
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| Published in: | Journal of Alzheimer's disease 2020-01, Vol.75 (3), p.1061-1069 |
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| container_title | Journal of Alzheimer's disease |
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| creator | García-García-Patino, Rosalía Benito-León, Julián Mitchell, Alex J. Pastorino-Mellado, Damián García García, Ricardo Ladera-Fernández, Valentina Vicente-Villardón, Jose Luis Perea-Bartolomé, María Victoria Cacho, Jesús |
| description | Background:
Specific cognitive alterations could be one of the predictors that lead to the complex activities of daily living (CADL) impairment in mild cognitive impairment (MCI) and, hence, help to explain the continuum between MCI and dementia.
Objective:
We aimed to reevaluate the existing uncertainty regarding the impact of memory and executive functions on CADL in patients with MCI.
Methods:
Caregivers of 161 patients with amnestic multi-domain MCI and of 150 patients with incipient Alzheimer’s disease as well as 100 age-, sex-, and education-matched controls, completed the Interview for Deterioration in Daily Living Activities in Dementia, a suitable instrument for the description and discrimination of CADL. In addition, all patients and controls were assessed with a neuropsychological battery to measure explicit memory and executive functions performance.
Results:
Multiple regression analyses showed that in the group of patients with amnestic multi-domain MCI, 67.4% of the variability of the CADL impairment was explained by worse performance on executive functions tests (p |
| doi_str_mv | 10.3233/JAD-191263 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2401119876</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.3233_JAD-191263</sage_id><sourcerecordid>2408553377</sourcerecordid><originalsourceid>FETCH-LOGICAL-c383t-264934804c3ec18d0dfe5496dbe3af06f5d8c2b4aa9b5c31084b5fde9037fd3</originalsourceid><addsrcrecordid>eNptkVFrFDEUhYNYbK2--AMk4EOlMDWZzEySx2W31pZdKuj7kElulpRJsiYzpfsT_NembrUgPt3L4bvnHjgIvaPkgtWMfbpZrCoqad2xF-iECt5WQhLxsuxM8KoWnB-j1znfEUIYkfwVOi5nknR1fYJ-bsDHtMcqGHz5AHqe3D3g1T7bOejJxYC_JjBOT3gZ_W6EB7wo8r2bHGQcLV4pN-7xuihhi6_9TrnkIUzYBbzwAfLkNN7M4-SqVfSqqBs3muK1De73p-eTN-jIqjHD26d5ir59vvy-_FKtb6-ul4t1pZlgU1V3jWSNII1moKkwxFhoG9mZAZiypLOtEboeGqXk0GpGiWiG1hqQhHFr2Cn6eHDdpfhjLvl677KGcVQB4pz7uiGUUil4V9AP_6B3cU6hZHukRNsyxnmhzg-UTjHnBLbfJedV2veU9I_19KWe_lBPgd8_Wc6DB_MX_dNHAc4OQFZbeP73H6tf5lyX2w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2408553377</pqid></control><display><type>article</type><title>Memory and Executive Dysfunction Predict Complex Activities of Daily Living Impairment in Amnestic Multi-Domain Mild Cognitive Impairment</title><source>SAGE:Jisc Collections:SAGE Journals Read and Publish 2023-2024:2025 extension (reading list)</source><creator>García-García-Patino, Rosalía ; Benito-León, Julián ; Mitchell, Alex J. ; Pastorino-Mellado, Damián ; García García, Ricardo ; Ladera-Fernández, Valentina ; Vicente-Villardón, Jose Luis ; Perea-Bartolomé, María Victoria ; Cacho, Jesús</creator><creatorcontrib>García-García-Patino, Rosalía ; Benito-León, Julián ; Mitchell, Alex J. ; Pastorino-Mellado, Damián ; García García, Ricardo ; Ladera-Fernández, Valentina ; Vicente-Villardón, Jose Luis ; Perea-Bartolomé, María Victoria ; Cacho, Jesús</creatorcontrib><description>Background:
Specific cognitive alterations could be one of the predictors that lead to the complex activities of daily living (CADL) impairment in mild cognitive impairment (MCI) and, hence, help to explain the continuum between MCI and dementia.
Objective:
We aimed to reevaluate the existing uncertainty regarding the impact of memory and executive functions on CADL in patients with MCI.
Methods:
Caregivers of 161 patients with amnestic multi-domain MCI and of 150 patients with incipient Alzheimer’s disease as well as 100 age-, sex-, and education-matched controls, completed the Interview for Deterioration in Daily Living Activities in Dementia, a suitable instrument for the description and discrimination of CADL. In addition, all patients and controls were assessed with a neuropsychological battery to measure explicit memory and executive functions performance.
Results:
Multiple regression analyses showed that in the group of patients with amnestic multi-domain MCI, 67.4% of the variability of the CADL impairment was explained by worse performance on executive functions tests (p < 0.0001) and 41.8% by different explicit memory components impairment (p < 0.0001). Further, in patients with incipient AD, 44.0% of the variability of CADL impairment was explained by worse performance on executive functions tests (p < 0.0001) and 39.9% by different explicit memory components worsening (p < 0.0001).
Conclusions:
Memory and executive functions alterations impact similarly on the CADL in both amnestic multi-domain MCI and incipient Alzheimer’s disease. Given the continuum that exists between both conditions, we conclude that CADL impairment may be an important early step in the evolution towards Alzheimer’s disease from amnestic multi-domain MCI.</description><identifier>ISSN: 1387-2877</identifier><identifier>EISSN: 1875-8908</identifier><identifier>DOI: 10.3233/JAD-191263</identifier><identifier>PMID: 32390622</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Activities of daily living ; Activities of Daily Living - psychology ; Aged ; Alzheimer's disease ; Amnesia - complications ; Amnesia - diagnosis ; Amnesia - psychology ; Cognitive ability ; Cognitive Dysfunction - complications ; Cognitive Dysfunction - diagnosis ; Cognitive Dysfunction - psychology ; Dementia ; Dementia disorders ; Domains ; Executive Function ; Female ; Humans ; Impairment ; Male ; Memory ; Mental Status and Dementia Tests ; Neurodegenerative diseases ; Regression analysis</subject><ispartof>Journal of Alzheimer's disease, 2020-01, Vol.75 (3), p.1061-1069</ispartof><rights>2020 – IOS Press and the authors. All rights reserved</rights><rights>Copyright IOS Press BV 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-264934804c3ec18d0dfe5496dbe3af06f5d8c2b4aa9b5c31084b5fde9037fd3</citedby><cites>FETCH-LOGICAL-c383t-264934804c3ec18d0dfe5496dbe3af06f5d8c2b4aa9b5c31084b5fde9037fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32390622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García-García-Patino, Rosalía</creatorcontrib><creatorcontrib>Benito-León, Julián</creatorcontrib><creatorcontrib>Mitchell, Alex J.</creatorcontrib><creatorcontrib>Pastorino-Mellado, Damián</creatorcontrib><creatorcontrib>García García, Ricardo</creatorcontrib><creatorcontrib>Ladera-Fernández, Valentina</creatorcontrib><creatorcontrib>Vicente-Villardón, Jose Luis</creatorcontrib><creatorcontrib>Perea-Bartolomé, María Victoria</creatorcontrib><creatorcontrib>Cacho, Jesús</creatorcontrib><title>Memory and Executive Dysfunction Predict Complex Activities of Daily Living Impairment in Amnestic Multi-Domain Mild Cognitive Impairment</title><title>Journal of Alzheimer's disease</title><addtitle>J Alzheimers Dis</addtitle><description>Background:
Specific cognitive alterations could be one of the predictors that lead to the complex activities of daily living (CADL) impairment in mild cognitive impairment (MCI) and, hence, help to explain the continuum between MCI and dementia.
Objective:
We aimed to reevaluate the existing uncertainty regarding the impact of memory and executive functions on CADL in patients with MCI.
Methods:
Caregivers of 161 patients with amnestic multi-domain MCI and of 150 patients with incipient Alzheimer’s disease as well as 100 age-, sex-, and education-matched controls, completed the Interview for Deterioration in Daily Living Activities in Dementia, a suitable instrument for the description and discrimination of CADL. In addition, all patients and controls were assessed with a neuropsychological battery to measure explicit memory and executive functions performance.
Results:
Multiple regression analyses showed that in the group of patients with amnestic multi-domain MCI, 67.4% of the variability of the CADL impairment was explained by worse performance on executive functions tests (p < 0.0001) and 41.8% by different explicit memory components impairment (p < 0.0001). Further, in patients with incipient AD, 44.0% of the variability of CADL impairment was explained by worse performance on executive functions tests (p < 0.0001) and 39.9% by different explicit memory components worsening (p < 0.0001).
Conclusions:
Memory and executive functions alterations impact similarly on the CADL in both amnestic multi-domain MCI and incipient Alzheimer’s disease. Given the continuum that exists between both conditions, we conclude that CADL impairment may be an important early step in the evolution towards Alzheimer’s disease from amnestic multi-domain MCI.</description><subject>Activities of daily living</subject><subject>Activities of Daily Living - psychology</subject><subject>Aged</subject><subject>Alzheimer's disease</subject><subject>Amnesia - complications</subject><subject>Amnesia - diagnosis</subject><subject>Amnesia - psychology</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - complications</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Cognitive Dysfunction - psychology</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Domains</subject><subject>Executive Function</subject><subject>Female</subject><subject>Humans</subject><subject>Impairment</subject><subject>Male</subject><subject>Memory</subject><subject>Mental Status and Dementia Tests</subject><subject>Neurodegenerative diseases</subject><subject>Regression analysis</subject><issn>1387-2877</issn><issn>1875-8908</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNptkVFrFDEUhYNYbK2--AMk4EOlMDWZzEySx2W31pZdKuj7kElulpRJsiYzpfsT_NembrUgPt3L4bvnHjgIvaPkgtWMfbpZrCoqad2xF-iECt5WQhLxsuxM8KoWnB-j1znfEUIYkfwVOi5nknR1fYJ-bsDHtMcqGHz5AHqe3D3g1T7bOejJxYC_JjBOT3gZ_W6EB7wo8r2bHGQcLV4pN-7xuihhi6_9TrnkIUzYBbzwAfLkNN7M4-SqVfSqqBs3muK1De73p-eTN-jIqjHD26d5ir59vvy-_FKtb6-ul4t1pZlgU1V3jWSNII1moKkwxFhoG9mZAZiypLOtEboeGqXk0GpGiWiG1hqQhHFr2Cn6eHDdpfhjLvl677KGcVQB4pz7uiGUUil4V9AP_6B3cU6hZHukRNsyxnmhzg-UTjHnBLbfJedV2veU9I_19KWe_lBPgd8_Wc6DB_MX_dNHAc4OQFZbeP73H6tf5lyX2w</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>García-García-Patino, Rosalía</creator><creator>Benito-León, Julián</creator><creator>Mitchell, Alex J.</creator><creator>Pastorino-Mellado, Damián</creator><creator>García García, Ricardo</creator><creator>Ladera-Fernández, Valentina</creator><creator>Vicente-Villardón, Jose Luis</creator><creator>Perea-Bartolomé, María Victoria</creator><creator>Cacho, Jesús</creator><general>SAGE Publications</general><general>IOS Press BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20200101</creationdate><title>Memory and Executive Dysfunction Predict Complex Activities of Daily Living Impairment in Amnestic Multi-Domain Mild Cognitive Impairment</title><author>García-García-Patino, Rosalía ; Benito-León, Julián ; Mitchell, Alex J. ; Pastorino-Mellado, Damián ; García García, Ricardo ; Ladera-Fernández, Valentina ; Vicente-Villardón, Jose Luis ; Perea-Bartolomé, María Victoria ; Cacho, Jesús</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-264934804c3ec18d0dfe5496dbe3af06f5d8c2b4aa9b5c31084b5fde9037fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Activities of daily living</topic><topic>Activities of Daily Living - psychology</topic><topic>Aged</topic><topic>Alzheimer's disease</topic><topic>Amnesia - complications</topic><topic>Amnesia - diagnosis</topic><topic>Amnesia - psychology</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - complications</topic><topic>Cognitive Dysfunction - diagnosis</topic><topic>Cognitive Dysfunction - psychology</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Domains</topic><topic>Executive Function</topic><topic>Female</topic><topic>Humans</topic><topic>Impairment</topic><topic>Male</topic><topic>Memory</topic><topic>Mental Status and Dementia Tests</topic><topic>Neurodegenerative diseases</topic><topic>Regression analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García-García-Patino, Rosalía</creatorcontrib><creatorcontrib>Benito-León, Julián</creatorcontrib><creatorcontrib>Mitchell, Alex J.</creatorcontrib><creatorcontrib>Pastorino-Mellado, Damián</creatorcontrib><creatorcontrib>García García, Ricardo</creatorcontrib><creatorcontrib>Ladera-Fernández, Valentina</creatorcontrib><creatorcontrib>Vicente-Villardón, Jose Luis</creatorcontrib><creatorcontrib>Perea-Bartolomé, María Victoria</creatorcontrib><creatorcontrib>Cacho, Jesús</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Alzheimer's disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García-García-Patino, Rosalía</au><au>Benito-León, Julián</au><au>Mitchell, Alex J.</au><au>Pastorino-Mellado, Damián</au><au>García García, Ricardo</au><au>Ladera-Fernández, Valentina</au><au>Vicente-Villardón, Jose Luis</au><au>Perea-Bartolomé, María Victoria</au><au>Cacho, Jesús</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Memory and Executive Dysfunction Predict Complex Activities of Daily Living Impairment in Amnestic Multi-Domain Mild Cognitive Impairment</atitle><jtitle>Journal of Alzheimer's disease</jtitle><addtitle>J Alzheimers Dis</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>75</volume><issue>3</issue><spage>1061</spage><epage>1069</epage><pages>1061-1069</pages><issn>1387-2877</issn><eissn>1875-8908</eissn><abstract>Background:
Specific cognitive alterations could be one of the predictors that lead to the complex activities of daily living (CADL) impairment in mild cognitive impairment (MCI) and, hence, help to explain the continuum between MCI and dementia.
Objective:
We aimed to reevaluate the existing uncertainty regarding the impact of memory and executive functions on CADL in patients with MCI.
Methods:
Caregivers of 161 patients with amnestic multi-domain MCI and of 150 patients with incipient Alzheimer’s disease as well as 100 age-, sex-, and education-matched controls, completed the Interview for Deterioration in Daily Living Activities in Dementia, a suitable instrument for the description and discrimination of CADL. In addition, all patients and controls were assessed with a neuropsychological battery to measure explicit memory and executive functions performance.
Results:
Multiple regression analyses showed that in the group of patients with amnestic multi-domain MCI, 67.4% of the variability of the CADL impairment was explained by worse performance on executive functions tests (p < 0.0001) and 41.8% by different explicit memory components impairment (p < 0.0001). Further, in patients with incipient AD, 44.0% of the variability of CADL impairment was explained by worse performance on executive functions tests (p < 0.0001) and 39.9% by different explicit memory components worsening (p < 0.0001).
Conclusions:
Memory and executive functions alterations impact similarly on the CADL in both amnestic multi-domain MCI and incipient Alzheimer’s disease. Given the continuum that exists between both conditions, we conclude that CADL impairment may be an important early step in the evolution towards Alzheimer’s disease from amnestic multi-domain MCI.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>32390622</pmid><doi>10.3233/JAD-191263</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Activities of daily living Activities of Daily Living - psychology Aged Alzheimer's disease Amnesia - complications Amnesia - diagnosis Amnesia - psychology Cognitive ability Cognitive Dysfunction - complications Cognitive Dysfunction - diagnosis Cognitive Dysfunction - psychology Dementia Dementia disorders Domains Executive Function Female Humans Impairment Male Memory Mental Status and Dementia Tests Neurodegenerative diseases Regression analysis |
| title | Memory and Executive Dysfunction Predict Complex Activities of Daily Living Impairment in Amnestic Multi-Domain Mild Cognitive Impairment |
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