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Gadolinium enhancement on cranial MRI in multiple sclerosis is age dependent

Background Epidemiological, pathological and radiological studies suggest that inflammatory demyelination in MS is an age-dependent process, and that the formation of focal inflammatory demyelinating lesions decreases with age. Gadolinium-enhancing lesions are a biomarker of inflammatory disease act...

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Published in:Journal of neurology 2020-09, Vol.267 (9), p.2619-2624
Main Authors: Koch, Marcus W., Mostert, Jop, Greenfield, Jamie, Liu, Wei-Qiao, Metz, Luanne
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container_issue 9
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creator Koch, Marcus W.
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Greenfield, Jamie
Liu, Wei-Qiao
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description Background Epidemiological, pathological and radiological studies suggest that inflammatory demyelination in MS is an age-dependent process, and that the formation of focal inflammatory demyelinating lesions decreases with age. Gadolinium-enhancing lesions are a biomarker of inflammatory disease activity in MS, but little is known about the relation of age and gadolinium enhancement on cranial MRI scans in people with MS. In this study, we investigated the association of age and other risk factors with gadolinium enhancement on cranial MRI in a retrospective cross-sectional clinical MS cohort. Methods In a cohort including 1543 people with CIS and MS, we investigated the association of the risk factors age, sex, disease course, immunomodulatory drug (IMD) treatment, and disability with gadolinium enhancement on cranial MRI scans using a binary logistic regression model. Results Age was the most important factor associated with gadolinium enhancement, with the odds of gadolinium enhancement decreasing with advancing age. Participants with CIS had lower odds of gadolinium enhancement (odds ratio of 0.42, 95% confidence interval of 0.24–0.72 compared to RRMS). Sex, disease course and IMD treatment were not significantly associated with gadolinium enhancement in our cohort. Conclusions Our investigation shows that gadolinium enhancement is strongly associated with age. Since gadolinium enhancement is a marker of inflammatory disease activity, our findings suggest that inflammatory disease activity declines with age, and that IMD treatment may be more beneficial in younger and less useful in older people with MS.
doi_str_mv 10.1007/s00415-020-09895-0
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Gadolinium-enhancing lesions are a biomarker of inflammatory disease activity in MS, but little is known about the relation of age and gadolinium enhancement on cranial MRI scans in people with MS. In this study, we investigated the association of age and other risk factors with gadolinium enhancement on cranial MRI in a retrospective cross-sectional clinical MS cohort. Methods In a cohort including 1543 people with CIS and MS, we investigated the association of the risk factors age, sex, disease course, immunomodulatory drug (IMD) treatment, and disability with gadolinium enhancement on cranial MRI scans using a binary logistic regression model. Results Age was the most important factor associated with gadolinium enhancement, with the odds of gadolinium enhancement decreasing with advancing age. Participants with CIS had lower odds of gadolinium enhancement (odds ratio of 0.42, 95% confidence interval of 0.24–0.72 compared to RRMS). Sex, disease course and IMD treatment were not significantly associated with gadolinium enhancement in our cohort. Conclusions Our investigation shows that gadolinium enhancement is strongly associated with age. Since gadolinium enhancement is a marker of inflammatory disease activity, our findings suggest that inflammatory disease activity declines with age, and that IMD treatment may be more beneficial in younger and less useful in older people with MS.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-020-09895-0</identifier><identifier>PMID: 32388832</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Age ; Demyelination ; Epidemiology ; Gadolinium ; Immunomodulation ; Inflammatory diseases ; Investigations ; Magnetic resonance imaging ; Medicine ; Medicine &amp; Public Health ; Multiple sclerosis ; Neurology ; Neuroradiology ; Neurosciences ; Original Communication ; Risk factors ; Skull</subject><ispartof>Journal of neurology, 2020-09, Vol.267 (9), p.2619-2624</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-397197eeee577852d18ff19e71a766fd2bfd1346d2105e786f3b22f904f14f4f3</citedby><cites>FETCH-LOGICAL-c375t-397197eeee577852d18ff19e71a766fd2bfd1346d2105e786f3b22f904f14f4f3</cites><orcidid>0000-0001-9972-5092</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32388832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koch, Marcus W.</creatorcontrib><creatorcontrib>Mostert, Jop</creatorcontrib><creatorcontrib>Greenfield, Jamie</creatorcontrib><creatorcontrib>Liu, Wei-Qiao</creatorcontrib><creatorcontrib>Metz, Luanne</creatorcontrib><title>Gadolinium enhancement on cranial MRI in multiple sclerosis is age dependent</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>Background Epidemiological, pathological and radiological studies suggest that inflammatory demyelination in MS is an age-dependent process, and that the formation of focal inflammatory demyelinating lesions decreases with age. Gadolinium-enhancing lesions are a biomarker of inflammatory disease activity in MS, but little is known about the relation of age and gadolinium enhancement on cranial MRI scans in people with MS. In this study, we investigated the association of age and other risk factors with gadolinium enhancement on cranial MRI in a retrospective cross-sectional clinical MS cohort. Methods In a cohort including 1543 people with CIS and MS, we investigated the association of the risk factors age, sex, disease course, immunomodulatory drug (IMD) treatment, and disability with gadolinium enhancement on cranial MRI scans using a binary logistic regression model. Results Age was the most important factor associated with gadolinium enhancement, with the odds of gadolinium enhancement decreasing with advancing age. Participants with CIS had lower odds of gadolinium enhancement (odds ratio of 0.42, 95% confidence interval of 0.24–0.72 compared to RRMS). 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subjects Age
Demyelination
Epidemiology
Gadolinium
Immunomodulation
Inflammatory diseases
Investigations
Magnetic resonance imaging
Medicine
Medicine & Public Health
Multiple sclerosis
Neurology
Neuroradiology
Neurosciences
Original Communication
Risk factors
Skull
title Gadolinium enhancement on cranial MRI in multiple sclerosis is age dependent
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