Eplet incompatibility in pediatric renal transplantation

Eplet incompatibility appears to be a better predictor of the de novo appearance of DSA post‐Tx than HLA antigen matching in adults. We evaluated the HLA Matchmaker® software (version 2.1) in our pediatric cohort to predict the appearance of DSA post‐Tx. We included 70 pediatric patients (26 girls,...

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Bibliographic Details
Published in:Pediatric transplantation 2020-09, Vol.24 (6), p.e13721-n/a
Main Authors: Rãchişan, Andreea Liana, Dubois, Valerie, Ranchin, Bruno, Sellier‐Leclerc, Anne‐Laure, Bertholet Thomas, Aurelia, Cochat, Pierre, Bacchetta, Justine
Format: Article
Language:English
Subjects:
Computer programs
Drb1 protein
epitopes
eplets
Histocompatibility antigen HLA
HLA match
Immunization
Kidney transplantation
pediatric transplantation
Pediatrics
renal graft
Tissue typing
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Summary:Eplet incompatibility appears to be a better predictor of the de novo appearance of DSA post‐Tx than HLA antigen matching in adults. We evaluated the HLA Matchmaker® software (version 2.1) in our pediatric cohort to predict the appearance of DSA post‐Tx. We included 70 pediatric patients (26 girls, 10 living donors, mean age 11.2 ± 3.9 years) after a first R‐Tx (January 2010‐August 2016), without prior immunization, having complete HLA typing (A, B, C, DRB1 and DQB1) and DSA follow‐up for at least one year. The mean of HLA and eplet incompatibilities was 4.7 ± 1.3 and 15.5 ± 6.1, respectively, with a correlation coefficient r2 between these two variables of 0.34 (P 
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.13721