Intrauterine versus post-mortem magnetic resonance in second trimester termination of pregnancy for central nervous system abnormalities

•Limiting factors for brain defect at < 23 weeks have little influence on iuMRI accuracy.•The accuracy of iuMRI for brain defects at < 23 weeks is comparable to post-mortem magnetic resonance.•iuMRI performed by experienced operators has lower rates of misdiagnosis. To evaluate if limiting fac...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2020-07, Vol.250, p.31-35
Main Authors: Fantasia, Ilaria, Bussani, Rossana, Gregori, Massimo, Zennaro, Floriana, D’Ottavio, Giuseppina, Monasta, Lorenzo, Cortivo, Caterina, Quadrifoglio, Mariachiara, Maso, Gianpaolo, Ricci, Giuseppe, Ottaviani, Chiara, Militello, Roberto, Stampalija, Tamara
Format: Article
Language:English
Subjects:
Autopsy
Central nervous system
Female
Fetal Diseases
Fetal magnetic resonance
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Nervous System Malformations - diagnostic imaging
Post-mortem
Pregnancy
Pregnancy Trimester, Second
Termination of pregnancy
Ultrasonography, Prenatal
Ultrasound
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Summary:•Limiting factors for brain defect at < 23 weeks have little influence on iuMRI accuracy.•The accuracy of iuMRI for brain defects at < 23 weeks is comparable to post-mortem magnetic resonance.•iuMRI performed by experienced operators has lower rates of misdiagnosis. To evaluate if limiting factors of intrauterine magnetic resonance imaging (iuMRI) performed in the early second trimester of pregnancy (19–23 weeks) affect its accuracy in comparison to post-mortem MRI (pmMRI) in fetuses that underwent termination of pregnancy (TOP) for central nervous system (CNS) defects. This is a secondary analysis of a 10 years prospective observational study. Cases of TOP 
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2020.04.032