Proximal reflux: biochemical mediators, markers, therapeutic targets, and clinical correlations

Airway reflux is implicated in the pathophysiology of a wide range of adult and pediatric upper and lower airway diseases. However, the diagnosis of proximal reflux–associated disease remains challenging due to evolving clinical criteria and institutional and regional variances in diagnostic practic...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2020-12, Vol.1481 (1), p.127-138
Main Authors: Klimara, Miles J., Randall, Derrick R., Allen, Jacqueline, Figueredo, Edgar, Johnston, Nikki
Format: Article
Language:English
Subjects:
airway
Biomarkers
Biomarkers - metabolism
cough
Diagnostic software
Diagnostic systems
extraesophageal reflux (EER)
Humans
laryngopharyngeal reflux (LPR)
Pediatrics
pepsin
reflux
Respiratory Aspiration of Gastric Contents - diagnosis
Respiratory Aspiration of Gastric Contents - metabolism
Respiratory Aspiration of Gastric Contents - physiopathology
Respiratory Aspiration of Gastric Contents - therapy
Respiratory tract diseases
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Summary:Airway reflux is implicated in the pathophysiology of a wide range of adult and pediatric upper and lower airway diseases. However, the diagnosis of proximal reflux–associated disease remains challenging due to evolving clinical criteria and institutional and regional variances in diagnostic practices. Evidence suggests that nonacidic contents of reflux may serve as both pathologic mediators of and biomarkers for reflux in the upper airway. Furthermore, they offer potential pharmaceutical and surgical intervention targets and are the focus of novel clinical diagnostic tools currently under investigation.
ISSN:0077-8923
1749-6632
DOI:10.1111/nyas.14366