New meroterpenoid compounds from the culture of mushroom Panus lecomtei

Two new meroterpenoid compounds (1 and 2) together with five known meroterpenoid derivatives (3–7) were isolated from solid culture of mushroom Panus lecomtei. The structures of new compounds were confirmed by the analysis of NMR and HR-ESI-MS spectroscopic data. The biosynthetic pathway of 1–7 was...

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Bibliographic Details
Published in:Chinese journal of natural medicines 2020-04, Vol.18 (4), p.268-272
Main Authors: WANG, Si-Xian, ZHAO, Rui-Lin, GUO, Cui, CHEN, Bao-Song, DAI, Huan-Qin, LIU, Gao-Qiang, LIU, Hong-Wei
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial
Bacteria - drug effects
Biosynthetic pathway
China
Meroterpenoid
Molecular Structure
Panus lecomtei
Plant Extracts - chemistry
Polyporales - chemistry
Terpenes - chemistry
Terpenes - isolation & purification
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Summary:Two new meroterpenoid compounds (1 and 2) together with five known meroterpenoid derivatives (3–7) were isolated from solid culture of mushroom Panus lecomtei. The structures of new compounds were confirmed by the analysis of NMR and HR-ESI-MS spectroscopic data. The biosynthetic pathway of 1–7 was postulated. All isolated compounds were evaluated for antibacterial activities against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa and Bacillus Calmette–Guérin. Compound 3 exhibited weak antibacterial activity against Bacillus Calmette–Guérin with the inhibition rate of 83.6% at 100 μmol·L−1. Other compounds showed no antibacterial activities against all tested pathogens at 100 μmol·L−1.
ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(20)30033-9