Peptide-Based Nanoparticles Mimic Fibrillogenesis of Laminin in Tumor Vessels for Precise Embolization

• Published in: ACS nano 2020-06, Vol.14 (6), p.7170-7180
• Main Authors: Zhang, Kuo, Yang, Pei-Pei, He, Ping-Ping, Wen, Shi-Fang, Zou, Xiao-Ran, Fan, Yu, Chen, Zi-Ming, Cao, Hui, Yang, Zhou, Yue, Kai, Zhang, Xinxin, Zhang, Hua, Wang, Lei, Wang, Hao
• Format: Article
• Language: English
• Subjects: Humans; Laminin; Nanoparticles; Neoplasms - drug therapy; Neovascularization, Pathologic - drug therapy; Peptides; Tumor Microenvironment
• ISSN: 1936-0851; 1936-086X
• DOI: 10.1021/acsnano.0c02110

Cancer therapeutic strategies based on angiogenesis attract great attention from fundamental and clinical research. Blocking oxygen and nutrition supply to tumor cells could inhibit the growth of tumors based on occlusion of blood vessels in the tumor. Herein, we report a dual-responsive peptide-based nanoparticle, mimicking the laminin fibrillogenesis specifically and highly efficiently in tumor vessels, resulting in the blockage of tumor vessels and the growth inhibition of tumors. The laminin mimic peptide (LMMP) is designed with a fibrillation sequence, a pH-responsive sequence, and a targeting sequence. The LMMP in nanoformulations is delivered to blood vessels in the tumors, where the microenvironment (pH and microthrombus) enable LMMP to process laminin fibrillogenesis, constructing fibrous networks. The laminin-like fibrous networks capture red blood cells etc., forming occlusion specifically in the tumor blood vessels to inhibit the growth of the tumor.