A general approach for biomimetic mineralization of MOF particles using biomolecules

[Display omitted] •MOFs have great potential in biomolecule encapsulation and controlled release.•A general approach is developed for making biomolecule@MOFs.•The charge of biomolecules plays a critical role in forming MOF crystals.•Biomolecules with negatively charges induce the formation ZIF-8 par...

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Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2020-09, Vol.193, p.111108-111108, Article 111108
Main Authors: Zou, Da, Yu, Lei, Sun, Qi, Hui, Yue, Tengjisi, Liu, Yun, Yang, Guangze, Wibowo, David, Zhao, Chun-Xia
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Biomineralization
Biomolecules
Metal-Organic Frameworks - chemical synthesis
Metal-Organic Frameworks - chemistry
MOFs
Particle Size
Peptides - chemistry
Proteins - chemistry
Surface Properties
ZIFs
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Summary:[Display omitted] •MOFs have great potential in biomolecule encapsulation and controlled release.•A general approach is developed for making biomolecule@MOFs.•The charge of biomolecules plays a critical role in forming MOF crystals.•Biomolecules with negatively charges induce the formation ZIF-8 particles.•Near neutral/positively charged biomolecules induce the formation of dia-Zn(HmIm)2. Biomineralization of metal organic frameworks (MOFs) using biomolecules has recently attracted significant interest because of the benign process including room temperature, neutral pH and without the requirement of any other chemical reagents. Also, these biomolecule incorporated MOFs (biomolecules@MOFs) have demonstrated their potential in biomolecule encapsulation, protection and controlled release. This work aims to develop a general strategy to make biomolecules@MOFs via a biomimetic mineralization process. A library of biomolecules (peptides and proteins) with different charges were systematically studied to fundamentally understand the role of biomolecules and their proprieties in biomolecule-mediated MOF biomineralization. Biomolecule charge, amino acid sequence and stirring speed have been demonstrated to play important roles in controlling biomineralization reaction rate, particle shape and morphology.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2020.111108