Decision making for promising quinoline‐based anticancer agents through combined methodology

During the development of effective drugs for the treatment of cancer, one of the most important tasks is to identify effective drug candidates having maximum antiproliferation and minimum side effects. This paper considers the problem of selecting the most promising anticancer agents, showing inhib...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biochemical and molecular toxicology 2020-09, Vol.34 (9), p.e22522-n/a
Main Authors: Özcan, Evrencan, Ökten, Salih, Eren, Tamer
Format: Article
Language:English
Subjects:
Algorithms
anticancer effect
Anticancer properties
Antitumor agents
Biotechnology
Cancer
Cytotoxicity
Decision making
Drug development
Functional groups
Hydroxyquinoline
IC50
L-Lactate dehydrogenase
Lactate dehydrogenase
Lactic acid
LDH
multicriteria decision making
Multiple criterion
Quinoline
Recommender systems
Side effects
Toxicity
Tumor cell lines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:During the development of effective drugs for the treatment of cancer, one of the most important tasks is to identify effective drug candidates having maximum antiproliferation and minimum side effects. This paper considers the problem of selecting the most promising anticancer agents, showing inhibition at low IC50 concentration and low releasing lactate dehydrogenase percentage (cytotoxicity). Recently, we prepared quinoline analogs bearing different functional groups and determined their anticancer potential against the HeLa, C6, and HT29 cancer cell lines using different anticancer assays. Experimentally, seven quinoline derivatives consisting of different substituents were determined as promising anticancer agents. We propose a multicriteria recommendation method to identify the most promising anticancer agents against all tested cell lines with an accurate prediction algorithm according to the available input data. A multicriteria decision‐making methodology (MCDM) was used for the solution of the relevant problem in this study. Both the experimental results and MCDM method indicated that 5,7‐dibromo‐8‐hydroxyquinoline (2) and 6,8‐dibromo‐1,2,3,4‐tetrahydroquinoline (6) are the most promising anticancer agents against the HeLa, HT29, and C6 cell lines.
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.22522