Association of lymphotoxin‐alpha gene polymorphisms (rs909253, rs1800683 and rs2229094) and risk of large‐artery atherosclerosis stroke in Iranian population

Background Lymphotoxin‐alpha (LTA), a proinflammatory cytokine, is significantly associated with the progression of atherosclerosis as an independent hazard factor for stroke. According to new genetic studies, polymorphisms in the LTA gene that influence its expression or biological function may pla...

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Bibliographic Details
Published in:The journal of gene medicine 2020-10, Vol.22 (10), p.e3229-n/a
Main Authors: Fasihi, Ali, Pourhamedi, Saeede, Zahedi, Mohmmadsaeid, Goudarzian, Maryam, Ramazi, Shahin, Kafashzadeh, Mehrnoosh, Heydari‐Zarnagh, Hafez
Format: Article
Language:English
Subjects:
Arteriosclerosis
Atherosclerosis
Gene polymorphism
Gene therapy
Haplotypes
Inflammation
Ischemia
Linkage disequilibrium
Lymphotoxin
lymphotoxin‐alpha
Polymerase chain reaction
rs1800683
rs2229094
rs909253
Single-nucleotide polymorphism
Stroke
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Summary:Background Lymphotoxin‐alpha (LTA), a proinflammatory cytokine, is significantly associated with the progression of atherosclerosis as an independent hazard factor for stroke. According to new genetic studies, polymorphisms in the LTA gene that influence its expression or biological function may play a role in the progress of stroke; thus, the present case–control study investigated LTA gene polymorphisms (rs909253, rs1800683 and rs2229094) and the risk of large artery atherosclerosis stroke (LAA) in an Iranian population. Methods For 211 large artery atherosclerosis patients and 186 ischemic stroke‐free controls, genotypes were determined using the tetra‐primer amplification‐refractory mutation system polymerase chain reaction method. Linkage disequilibrium and estimated haplotypes were analyzed using SNP Analyzer 2 software. The strength of the link between LTA gene polymorphisms (rs1800683, rs909253, and rs2229094) and the risk of stroke was determined using conditional logistic regression. Results Analysis revealed that the patterns of the rs1800683, rs909253 and rs2229094 genotypes showed no significant difference between the LAA and control group, although the distribution of the GAT (rs1800683G, rs909253A and rs2229094T) haplotype was significantly higher in the control group (odds ratio = 0.707, 95% confidence interval = 0.53–0.942, p = 0.0355). Conclusions Our results indicate that the GAT haplotype in LTA gene is associated with a decreased risk of LAA incidence in a northeastern Iranian population.
ISSN:1099-498X
1521-2254
DOI:10.1002/jgm.3229