Management and long-term consequences of genital graft versus host disease following hematopoietic stem cell transplantation

Vulvovaginal Graft-versus-host disease (VV-GVHD) is an underdiagnosed complication of hematopoietic stem cell transplantation (HSCT). The severity of the disease varies greatly, ranging from minor discomfort to severe, irreversible anatomic changes. This study sought to assess the long-term course o...

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Bibliographic Details
Published in:Bone marrow transplantation (Basingstoke) 2020-12, Vol.55 (12), p.2234-2243
Main Authors: Lev-Sagie, Ahinoam, Adar-Walling, Ela, Gumer, Arielle, Grisariu, Sigal, Avni, Batia
Format: Article
Language:English
Subjects:
692/1807
692/700/784
Cell Biology
Demographic aspects
Diagnosis
Estrogens
Genital diseases, Female
Graft versus host disease
Graft versus host reaction
Hematology
Hematopoietic stem cells
Internal Medicine
Medicine
Medicine & Public Health
Public Health
Quality of life
Risk factors
Sexuality
Silicone resins
Silicones
Stem cell transplantation
Stem Cells
Steroid hormones
Steroids
Transplantation
Vagina
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Summary:Vulvovaginal Graft-versus-host disease (VV-GVHD) is an underdiagnosed complication of hematopoietic stem cell transplantation (HSCT). The severity of the disease varies greatly, ranging from minor discomfort to severe, irreversible anatomic changes. This study sought to assess the long-term course of VV-GVHD. A retrospective analysis was conducted of 64 women who underwent HSCT and were followed over 9 years in a designated vulvovaginal clinic. VV-GVHD was detected in 56% of transplanted women. Adherence with follow-up correlated with diagnosis of VV-GVHD ( p  
ISSN:0268-3369
1476-5365
DOI:10.1038/s41409-020-0933-2