Epileptic Activity Intrinsically Generated in the Human Cerebellum

Neoplastic or dysplastic neuronal tissue in the brain stem and cerebellum can become epileptogenic in pediatric patients. However, it is unknown whether such tissue may transform intrinsic properties of the human cerebellum, making it capable of generating epileptic population activity. We noninvasi...

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Bibliographic Details
Published in:Annals of neurology 2020-08, Vol.88 (2), p.418-422
Main Authors: Okada, Yoshio, Khan, Sheraz, Curran, Ashley, Ahtam, Banu, Hämäläinen, Matti S., Traub, Roger D., Pearl, Phillip L.
Format: Article
Language:English
Subjects:
Brain stem
Cerebellum
Cerebellum - diagnostic imaging
Cerebellum - physiopathology
Child, Preschool
Electroencephalography - methods
Epilepsy
Epilepsy - diagnostic imaging
Epilepsy - physiopathology
Female
Humans
Pediatrics
Tumors
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Summary:Neoplastic or dysplastic neuronal tissue in the brain stem and cerebellum can become epileptogenic in pediatric patients. However, it is unknown whether such tissue may transform intrinsic properties of the human cerebellum, making it capable of generating epileptic population activity. We noninvasively detected epileptiform signals unaveraged in a pediatric patient with epilepsy due to a tumor in the middle cerebellar peduncle. Analysis of generators of the signals revealed that the cerebellum ipsilateral and contralateral to the tumor was the dominant interictal spike generator and could initiate ictal activity, suggesting that human cerebellum may become capable of intrinsically generating epileptic activity. ANN NEUROL 2020;88:418–422.
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.25779