Biofunctional scaffolds with high packing density of aligned electrospun fibers support neural regeneration

Neurons of the central nervous system do not regenerate spontaneously after injury. As such, biofunctional tissue scaffolds have been explored to provide a growth‐promoting environment to enhance neural regeneration. In this regard, aligned electrospun fibers have proven invaluable for regeneration...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2020-12, Vol.108 (12), p.2473-2483
Main Authors: Cnops, Vanja, Chin, Jiah Shin, Milbreta, Ulla, Chew, Sing Yian
Format: Article
Language:English
Subjects:
aligned fibers
Axon guidance
Axons
Blood vessels
Bundles
Central nervous system
Electrospinning
Fibers
Injury prevention
nerve regeneration
Neurons
Osseointegration
Packing density
Regeneration
Scaffolds
Spinal cord injuries
spinal cord injury
Tissue engineering
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neurons of the central nervous system do not regenerate spontaneously after injury. As such, biofunctional tissue scaffolds have been explored to provide a growth‐promoting environment to enhance neural regeneration. In this regard, aligned electrospun fibers have proven invaluable for regeneration by offering guidance for axons to cross the injury site. However, a high fiber density could potentially limit axonal ingrowth into the scaffold. Here, we explore which fiber density provides the optimal environment for neurons to regenerate. By changing fiber electrospinning time, we generated scaffolds with different fiber densities and implanted these in a rat model of spinal cord injury (SCI). We found that neurons were able to grow efficiently into scaffolds with high fiber density, even if the gaps between fiber bundles were very small (
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.36998