Near‐Infrared Multipurpose Lanthanide‐Imaging Nanoprobes

Optical imaging plays a growing role in modern biomedical research and clinical applications due to its high sensitivity, superb spatiotemporal resolution and minimal hazards. Lanthanide‐doped nanoparticles (LDNPs), as a classical category of luminescent materials, exhibit promising photostability,...

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Bibliographic Details
Published in:Chemistry, an Asian journal an Asian journal, 2020-07, Vol.15 (14), p.2076-2091
Main Authors: Wang, Zhimin, Xing, Bengang
Format: Article
Language:English
Subjects:
Biomedical materials
Chemistry
downconversion
Infrared imaging
Infrared windows
lanthanide nanoprobes
lifetime
Multiplexing
Nanoparticles
near-infrared bioimaging
photoacoustic
Translations
Upconversion
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Summary:Optical imaging plays a growing role in modern biomedical research and clinical applications due to its high sensitivity, superb spatiotemporal resolution and minimal hazards. Lanthanide‐doped nanoparticles (LDNPs), as a classical category of luminescent materials, exhibit promising photostability, near‐infrared (NIR)‐excited frequency up‐/down‐converting capabilities, emission fine‐tuning and multispectral features, which have greatly promoted the endeavors of deeper and clearer diagnostics in complex living conditions. This review focuses on the recent advances of LDNP‐based multipurpose imaging studies using upconversion, downshifting, lifetime, photoacoustic and multimodal nanoprobes in the NIR (650–1000 nm) and the second near‐infrared window (NIR‐II, 1000–1700 nm). The principle and design of various functional, activatable, multiplexing or multimodal lanthanide‐imaging nanoprobes (LINPs) as well as representative biophotonic applications are summarized in detail. In addition, the future perspectives and challenges for facilitating LINPs to clinical translations are discussed. Lanthanide‐based bioimaging has attracted tremendous attention in biomedical research. Herein, recent advances in the design of multipurpose upconversion, downshifting, lifetime, photoacoustic and multimodal lanthanide‐imaging nanoprobes (LINPs), as well as their representative activatable, multiplexing or multimodal biophotonic applications are summarized in detail.
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.202000493