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Impact of weight loss on cancer patients’ quality of life at the beginning of the chemotherapy
Purpose Among the prognostic factors relevant to the condition of oncological patients, nutritional status (NS) has the greatest single impact on quality of life (QL). The goals of our study were to evaluate the influence of NS, weight loss (WL), and the presence of cachexia, prior to the initiation...
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| Published in: | Supportive care in cancer 2021-02, Vol.29 (2), p.627-634 |
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| container_title | Supportive care in cancer |
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| creator | Álvaro Sanz, Elena Abilés, Jimena Garrido Siles, Margarita Pérez Ruíz, Elísabeth Alcaide García, Julia Rueda Domínguez, Antonio |
| description | Purpose
Among the prognostic factors relevant to the condition of oncological patients, nutritional status (NS) has the greatest single impact on quality of life (QL). The goals of our study were to evaluate the influence of NS, weight loss (WL), and the presence of cachexia, prior to the initiation of chemotherapy, on the patient’s QL.
Methods
Adult patients (aged ≥ 18 years) diagnosed with solid tumours for whom chemotherapy was started between April 2016 and June 2017 were eligible for inclusion in the study. They were asked to complete a QL questionnaire (Functional Assessment of Cancer Treatment (FACT-G)) at the beginning. The presence or absence of cachexia was evaluated at the outset, following the definition proposed by Fearon and nutritional assessment by the Patient-Generated Subjective Global Assessment (PG-SGA) scale.
Results
A total of 177 patients completed the FACT-G, the 60% receiving curative therapy. At the start of the treatment, 58.2% of patients had experienced WL, with an average of 4.4 ± 7.4%, and 19% were at risk of malnutrition. Patient who presented cachexia at diagnosis, were treated with palliative intention, had a Nutriscore ≥ 5 points or presented malnutrition in accordance with PG-SGA had a poorer QL (
p
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| doi_str_mv | 10.1007/s00520-020-05496-9 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2404643848</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A650588031</galeid><sourcerecordid>A650588031</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-21425d46a8555d7ccfab42878ca6f27dade7984392a1024db4bf405fc3fc0b0a3</originalsourceid><addsrcrecordid>eNp9kd1qFTEQx4Mo9lh9AS8k4E1vtk6-9uOyFD8KBW_0OmazyZ6U3WSbZJFz19fw9XySZjnVooiEIWHy-w8z80foNYFzAtC8SwCCQgVbCN7VVfcE7QhnrGoY656iHXScVJwJcYJepHQDQJpG0OfohFFOec3pDn27mhelMw4Wfzdu3Gc8hZRw8Fgrr03Ei8rO-Jx-3v3At6uaXD5s8OSswSrjvDe4N6Pz3vlx-9gSem_mUB5RLYeX6JlVUzKvHu5T9PXD-y-Xn6rrzx-vLi-uK805zRUlnIqB16oVQgyN1lb1nLZNq1VtaTOowTRdy1lHFQHKh573loOwmlkNPSh2is6OdZcYbleTspxd0maalDdhTZJyKBOzlrcFffsXehPW6Et3hdpWJ2poHqlRTUY6b0OOSm9F5UUtQLQtMFKo839Q5Qxmdjp4Y13J_yGgR4GOZdHRWLlEN6t4kATkZqs82iphi81W2RXRm4eO1342w2_JLx8LwI5AKl9-NPFxpP-UvQdFtqwh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2473395607</pqid></control><display><type>article</type><title>Impact of weight loss on cancer patients’ quality of life at the beginning of the chemotherapy</title><source>Social Science Premium Collection</source><source>Sociology Collection</source><source>Springer Link</source><creator>Álvaro Sanz, Elena ; Abilés, Jimena ; Garrido Siles, Margarita ; Pérez Ruíz, Elísabeth ; Alcaide García, Julia ; Rueda Domínguez, Antonio</creator><creatorcontrib>Álvaro Sanz, Elena ; Abilés, Jimena ; Garrido Siles, Margarita ; Pérez Ruíz, Elísabeth ; Alcaide García, Julia ; Rueda Domínguez, Antonio</creatorcontrib><description>Purpose
Among the prognostic factors relevant to the condition of oncological patients, nutritional status (NS) has the greatest single impact on quality of life (QL). The goals of our study were to evaluate the influence of NS, weight loss (WL), and the presence of cachexia, prior to the initiation of chemotherapy, on the patient’s QL.
Methods
Adult patients (aged ≥ 18 years) diagnosed with solid tumours for whom chemotherapy was started between April 2016 and June 2017 were eligible for inclusion in the study. They were asked to complete a QL questionnaire (Functional Assessment of Cancer Treatment (FACT-G)) at the beginning. The presence or absence of cachexia was evaluated at the outset, following the definition proposed by Fearon and nutritional assessment by the Patient-Generated Subjective Global Assessment (PG-SGA) scale.
Results
A total of 177 patients completed the FACT-G, the 60% receiving curative therapy. At the start of the treatment, 58.2% of patients had experienced WL, with an average of 4.4 ± 7.4%, and 19% were at risk of malnutrition. Patient who presented cachexia at diagnosis, were treated with palliative intention, had a Nutriscore ≥ 5 points or presented malnutrition in accordance with PG-SGA had a poorer QL (
p
< 0.05). Greater WL was associated with a worsened QL (
p
= 0.001). Breast cancer patients presented an inverse correlation between the %WL and the initial score in the FACT-G (
r
= − 0.304,
p
= 0.023), whereas no such correlation was observed for the other types of tumour (
r
= − 0.012,
p
= 0.892).
Conclusions
These results underline the relation of NS before starting chemotherapy and QL. Greater WL was associated with a worsened QL, especially in women with breast cancer.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-020-05496-9</identifier><identifier>PMID: 32424642</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - metabolism ; Cachexia - metabolism ; Cancer ; Cancer patients ; Cancer therapies ; Care and treatment ; Chemotherapy ; Female ; Humans ; Male ; Malnutrition ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasms - drug therapy ; Neoplasms - metabolism ; Nursing ; Nursing Research ; Nutrition ; Nutrition Assessment ; Nutritional Status ; Oncology ; Oncology, Experimental ; Original Article ; Pain Medicine ; Patients ; Product/Service Evaluations ; Prognosis ; Quality of Life ; Rehabilitation Medicine ; Surveys and Questionnaires ; Weight loss ; Weight Loss - physiology</subject><ispartof>Supportive care in cancer, 2021-02, Vol.29 (2), p.627-634</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>COPYRIGHT 2021 Springer</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-21425d46a8555d7ccfab42878ca6f27dade7984392a1024db4bf405fc3fc0b0a3</citedby><cites>FETCH-LOGICAL-c442t-21425d46a8555d7ccfab42878ca6f27dade7984392a1024db4bf405fc3fc0b0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2473395607/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2473395607?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21394,21395,27924,27925,33611,33612,34530,34531,43733,44115,74093,74511</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32424642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Álvaro Sanz, Elena</creatorcontrib><creatorcontrib>Abilés, Jimena</creatorcontrib><creatorcontrib>Garrido Siles, Margarita</creatorcontrib><creatorcontrib>Pérez Ruíz, Elísabeth</creatorcontrib><creatorcontrib>Alcaide García, Julia</creatorcontrib><creatorcontrib>Rueda Domínguez, Antonio</creatorcontrib><title>Impact of weight loss on cancer patients’ quality of life at the beginning of the chemotherapy</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Purpose
Among the prognostic factors relevant to the condition of oncological patients, nutritional status (NS) has the greatest single impact on quality of life (QL). The goals of our study were to evaluate the influence of NS, weight loss (WL), and the presence of cachexia, prior to the initiation of chemotherapy, on the patient’s QL.
Methods
Adult patients (aged ≥ 18 years) diagnosed with solid tumours for whom chemotherapy was started between April 2016 and June 2017 were eligible for inclusion in the study. They were asked to complete a QL questionnaire (Functional Assessment of Cancer Treatment (FACT-G)) at the beginning. The presence or absence of cachexia was evaluated at the outset, following the definition proposed by Fearon and nutritional assessment by the Patient-Generated Subjective Global Assessment (PG-SGA) scale.
Results
A total of 177 patients completed the FACT-G, the 60% receiving curative therapy. At the start of the treatment, 58.2% of patients had experienced WL, with an average of 4.4 ± 7.4%, and 19% were at risk of malnutrition. Patient who presented cachexia at diagnosis, were treated with palliative intention, had a Nutriscore ≥ 5 points or presented malnutrition in accordance with PG-SGA had a poorer QL (
p
< 0.05). Greater WL was associated with a worsened QL (
p
= 0.001). Breast cancer patients presented an inverse correlation between the %WL and the initial score in the FACT-G (
r
= − 0.304,
p
= 0.023), whereas no such correlation was observed for the other types of tumour (
r
= − 0.012,
p
= 0.892).
Conclusions
These results underline the relation of NS before starting chemotherapy and QL. Greater WL was associated with a worsened QL, especially in women with breast cancer.</description><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - metabolism</subject><subject>Cachexia - metabolism</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Malnutrition</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - metabolism</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Nutrition</subject><subject>Nutrition Assessment</subject><subject>Nutritional Status</subject><subject>Oncology</subject><subject>Oncology, Experimental</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Patients</subject><subject>Product/Service Evaluations</subject><subject>Prognosis</subject><subject>Quality of Life</subject><subject>Rehabilitation Medicine</subject><subject>Surveys and Questionnaires</subject><subject>Weight loss</subject><subject>Weight Loss - physiology</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>HEHIP</sourceid><sourceid>M2R</sourceid><sourceid>M2S</sourceid><recordid>eNp9kd1qFTEQx4Mo9lh9AS8k4E1vtk6-9uOyFD8KBW_0OmazyZ6U3WSbZJFz19fw9XySZjnVooiEIWHy-w8z80foNYFzAtC8SwCCQgVbCN7VVfcE7QhnrGoY656iHXScVJwJcYJepHQDQJpG0OfohFFOec3pDn27mhelMw4Wfzdu3Gc8hZRw8Fgrr03Ei8rO-Jx-3v3At6uaXD5s8OSswSrjvDe4N6Pz3vlx-9gSem_mUB5RLYeX6JlVUzKvHu5T9PXD-y-Xn6rrzx-vLi-uK805zRUlnIqB16oVQgyN1lb1nLZNq1VtaTOowTRdy1lHFQHKh573loOwmlkNPSh2is6OdZcYbleTspxd0maalDdhTZJyKBOzlrcFffsXehPW6Et3hdpWJ2poHqlRTUY6b0OOSm9F5UUtQLQtMFKo839Q5Qxmdjp4Y13J_yGgR4GOZdHRWLlEN6t4kATkZqs82iphi81W2RXRm4eO1342w2_JLx8LwI5AKl9-NPFxpP-UvQdFtqwh</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Álvaro Sanz, Elena</creator><creator>Abilés, Jimena</creator><creator>Garrido Siles, Margarita</creator><creator>Pérez Ruíz, Elísabeth</creator><creator>Alcaide García, Julia</creator><creator>Rueda Domínguez, Antonio</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20210201</creationdate><title>Impact of weight loss on cancer patients’ quality of life at the beginning of the chemotherapy</title><author>Álvaro Sanz, Elena ; Abilés, Jimena ; Garrido Siles, Margarita ; Pérez Ruíz, Elísabeth ; Alcaide García, Julia ; Rueda Domínguez, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-21425d46a8555d7ccfab42878ca6f27dade7984392a1024db4bf405fc3fc0b0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - metabolism</topic><topic>Cachexia - metabolism</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Malnutrition</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - metabolism</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Nutrition</topic><topic>Nutrition Assessment</topic><topic>Nutritional Status</topic><topic>Oncology</topic><topic>Oncology, Experimental</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Patients</topic><topic>Product/Service Evaluations</topic><topic>Prognosis</topic><topic>Quality of Life</topic><topic>Rehabilitation Medicine</topic><topic>Surveys and Questionnaires</topic><topic>Weight loss</topic><topic>Weight Loss - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Álvaro Sanz, Elena</creatorcontrib><creatorcontrib>Abilés, Jimena</creatorcontrib><creatorcontrib>Garrido Siles, Margarita</creatorcontrib><creatorcontrib>Pérez Ruíz, Elísabeth</creatorcontrib><creatorcontrib>Alcaide García, Julia</creatorcontrib><creatorcontrib>Rueda Domínguez, Antonio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Álvaro Sanz, Elena</au><au>Abilés, Jimena</au><au>Garrido Siles, Margarita</au><au>Pérez Ruíz, Elísabeth</au><au>Alcaide García, Julia</au><au>Rueda Domínguez, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of weight loss on cancer patients’ quality of life at the beginning of the chemotherapy</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>29</volume><issue>2</issue><spage>627</spage><epage>634</epage><pages>627-634</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Purpose
Among the prognostic factors relevant to the condition of oncological patients, nutritional status (NS) has the greatest single impact on quality of life (QL). The goals of our study were to evaluate the influence of NS, weight loss (WL), and the presence of cachexia, prior to the initiation of chemotherapy, on the patient’s QL.
Methods
Adult patients (aged ≥ 18 years) diagnosed with solid tumours for whom chemotherapy was started between April 2016 and June 2017 were eligible for inclusion in the study. They were asked to complete a QL questionnaire (Functional Assessment of Cancer Treatment (FACT-G)) at the beginning. The presence or absence of cachexia was evaluated at the outset, following the definition proposed by Fearon and nutritional assessment by the Patient-Generated Subjective Global Assessment (PG-SGA) scale.
Results
A total of 177 patients completed the FACT-G, the 60% receiving curative therapy. At the start of the treatment, 58.2% of patients had experienced WL, with an average of 4.4 ± 7.4%, and 19% were at risk of malnutrition. Patient who presented cachexia at diagnosis, were treated with palliative intention, had a Nutriscore ≥ 5 points or presented malnutrition in accordance with PG-SGA had a poorer QL (
p
< 0.05). Greater WL was associated with a worsened QL (
p
= 0.001). Breast cancer patients presented an inverse correlation between the %WL and the initial score in the FACT-G (
r
= − 0.304,
p
= 0.023), whereas no such correlation was observed for the other types of tumour (
r
= − 0.012,
p
= 0.892).
Conclusions
These results underline the relation of NS before starting chemotherapy and QL. Greater WL was associated with a worsened QL, especially in women with breast cancer.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32424642</pmid><doi>10.1007/s00520-020-05496-9</doi><tpages>8</tpages></addata></record> |
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| issn | 0941-4355 1433-7339 |
| language | eng |
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| source | Social Science Premium Collection; Sociology Collection; Springer Link |
| subjects | Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Cachexia - metabolism Cancer Cancer patients Cancer therapies Care and treatment Chemotherapy Female Humans Male Malnutrition Medicine Medicine & Public Health Middle Aged Neoplasms - drug therapy Neoplasms - metabolism Nursing Nursing Research Nutrition Nutrition Assessment Nutritional Status Oncology Oncology, Experimental Original Article Pain Medicine Patients Product/Service Evaluations Prognosis Quality of Life Rehabilitation Medicine Surveys and Questionnaires Weight loss Weight Loss - physiology |
| title | Impact of weight loss on cancer patients’ quality of life at the beginning of the chemotherapy |
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