Focused ultrasound for opening blood-brain barrier and drug delivery monitored with positron emission tomography

Focused ultrasound (FUS) is a minimally-invasive technology used for treatment of many diseases, including diseases related to the colon, uterus, prostate, and brain. Although it has been mainly used for ablative procedures, the ability of FUS to open the blood-brain barrier (BBB) presents a promisi...

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Bibliographic Details
Published in:Journal of controlled release 2020-08, Vol.324, p.303-316
Main Authors: Arif, Wejdan M., Elsinga, Philip H., Gasca-Salas, Carmen, Versluis, Michel, Martínez-Fernández, Raul, Dierckx, Rudi A.J.O., Borra, Ronald J.H., Luurtsema, Gert
Format: Article
Language:English
Subjects:
Blood-Brain Barrier
Blood-brain barrier transporters
Drug Delivery Systems
Female
FUS
Humans
Male
Microbubbles
Pharmaceutical Preparations
Positron-Emission Tomography
Radiotracers
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Summary:Focused ultrasound (FUS) is a minimally-invasive technology used for treatment of many diseases, including diseases related to the colon, uterus, prostate, and brain. Although it has been mainly used for ablative procedures, the ability of FUS to open the blood-brain barrier (BBB) presents a promising new application. However, the mechanism of BBB opening by FUS remains unclear. This review focuses on the use of FUS to open the BBB for enhancing drug delivery and investigating how Positron Emission Tomography (PET) provides insight into the underlying mechanism. [Display omitted] •FUS may be a useful technique to enhance cerebral drug delivery.•The mechanism of BBB opening by FUS remains unclear.•The effect of FUS and microbubbles on the mechanism of BBB transporters remains undetermined.•PET may be a promising quantitative approach to assess the molecular effects of sonication.
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2020.05.020