In vivo antioxidant and anti-inflammatory effects of soluble dietary fiber Konjac glucomannan in type-2 diabetic rats

• Published in: International journal of biological macromolecules 2020-09, Vol.159, p.1186-1196
• Main Authors: Zhao, Yingshu, Jayachandran, Muthukumaran, Xu, Baojun
• Format: Article
• Language: English
• Subjects: Animals; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Antioxidants - administration & dosage; Antioxidants - pharmacology; Antioxidants - therapeutic use; Diabetes Mellitus, Experimental - drug therapy; High-fat diet; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - pharmacology; Hypoglycemic Agents - therapeutic use; Kidney - drug effects; Kidney - metabolism; Konjac glucomannan; Liver - drug effects; Liver - metabolism; Male; Mannans - administration & dosage; Mannans - pharmacology; Mannans - therapeutic use; NF-E2-Related Factor 2 - metabolism; NF-kappa B - metabolism; Nuclear factor erythroid 2-related factor 2; Nuclear factor-kappa B; Rats; Rats, Wistar; Streptozotocin; Type-2 diabetes mellitus
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2020.05.105

Although the anti-diabetic properties of Konjac glucomannan (KGM) have been reported previously; however, the molecular pathways of its anti-diabetic properties are not clear. The present study hypothesized that KGM could mitigate oxidative stress and inflammation. Three doses of KGM (40, 80, 120 mg/kg b.w.) decreased the levels of plasma glucose and insulin in type-2 diabetic rats induced by a high-fat diet and streptozotocin (STZ) after administration for 28 days. Besides, the C-reactive protein, antioxidants, and the pathways of the nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB) showed amelioration and positively regulation after treated with a medium dose of KGM (80 mg/kg b.w.). The results of the histological study indicated that the medium dose of KGM was able to reverse the structural impairment of kidney and liver caused by type-2 diabetes. In conclusion, our research demonstrated that KGM reduced the hyperglycemia, regulated the Nrf2 pathway and by which it prevented oxidative stress, besides, it reduced the inflammation via regulation of the NF-kB pathway. [Display omitted] •Dietary KGM reduces oxidative stress via regulation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.•KGM has an anti-inflammatory function and regulates the nuclear factor-kappa B (NF-κB) pathway.•KGM exhibits antioxidative, anti-inflammatory and anti-diabetic properties.