Prevalence of human papillomavirus and implication on survival in Chinese penile cancer

We assessed the prevalence of HPV DNA in a large series of Chinese penile cancer and examine its association with the histological subtype, p16 INK4a expression, and prognosis. We pathologically categorized 226 invasive penile squamous cell carcinomas and assessed HPV genotyping by real-time PCR and...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2020-11, Vol.477 (5), p.667-675
Main Authors: Chu, Chengbiao, Chen, Keming, Tan, Xingliang, Lu, Jiangli, Yang, Yuanzhong, Zhang, YiJun, Yao, Kai, Cao, Yun
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - analysis
Cancer
China - epidemiology
Cyclin-Dependent Kinase Inhibitor p16 - analysis
Deoxyribonucleic acid
DNA
Genital cancers
Genotypes
Genotyping
Human papillomavirus
Human Papillomavirus DNA Tests
Humans
Immunohistochemistry
INK4a protein
Invasiveness
Lymph nodes
Male
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Original Article
p16 Protein
Papillomavirus Infections - diagnosis
Papillomavirus Infections - epidemiology
Papillomavirus Infections - mortality
Papillomavirus Infections - virology
Pathology
Penile Neoplasms - diagnosis
Penile Neoplasms - epidemiology
Penile Neoplasms - mortality
Penile Neoplasms - virology
Penis
Predictive Value of Tests
Prevalence
Prognosis
Quality in Pathology
Regression models
Retrospective Studies
Risk Assessment
Risk Factors
Squamous cell carcinoma
Survival
Time Factors
Tumors
Young Adult
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Summary:We assessed the prevalence of HPV DNA in a large series of Chinese penile cancer and examine its association with the histological subtype, p16 INK4a expression, and prognosis. We pathologically categorized 226 invasive penile squamous cell carcinomas and assessed HPV genotyping by real-time PCR and p16 INK4a immunohistochemistry. The results were correlated with histopathological and clinical parameters and disease-specific survival (DSS). HPV DNA was detected in 32.7% (74/226) of penile cancer cases. The most frequent genotype was HPV 16 (64/74, 86.5%), followed by HPV 18 (6/74, 8.1%). Fifty-nine (26.1%) cases were positive for the p16 INK4a expression, and p16 INK4a expression had a sensitivity of 56.8% (95% CI, 45.2–68.3%) and a specificity of 88.8% (95% CI, 83.8–93.9%) for defining HPV status. HPV DNA ( P  = 0.019), p16 INK4a ( P  = 0.038), age ( P  = 0.018), grade of differentiation ( P  = 0.001), lymph nodes ( P  
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-020-02831-7