The roles of tumor-associated macrophages in tumor angiogenesis and metastasis

• Published in: Cellular immunology 2020-07, Vol.353, p.104119-104119, Article 104119
• Main Authors: Fu, Luo-Qin, Du, Wen-Lin, Cai, Mao-Hua, Yao, Jia-Yu, Zhao, Yuan-Yuan, Mou, Xiao-Zhou
• Format: Article
• Language: English
• Subjects: Angiogenesis; Angiogenesis Inducing Agents - metabolism; Animals; Cytokines - metabolism; Disease Progression; Humans; Intercellular Signaling Peptides and Proteins - metabolism; Macrophages - immunology; Macrophages - metabolism; Metastasis; Neoplasm Metastasis - physiopathology; Neoplasms - immunology; Neoplasms - metabolism; Neovascularization, Pathologic - immunology; Neovascularization, Pathologic - metabolism; Tumor microenvironment; Tumor Microenvironment - immunology; Tumor-associated macrophage
• ISSN: 0008-8749; 1090-2163
• DOI: 10.1016/j.cellimm.2020.104119

•TAMs are involved in tumor progression via multiple mechanisms.•TAMs serve as angiogenesis promoting cells in cancer.•TAMs play vital roles in tumor metastasis.•TAMs are the promising candidate in cancer therapy. Tumor associated macrophages (TAMs) are the most frequent immune cells within tumor microenvironment (TME). There is growing evidence that TAMs are involved in tumor progression via multiple mechanisms. TAMs create an immunosuppressive TME by producing growth factors, chemokines, and cytokines which modulate recruitment of immune cells and inhibit anti-tumor responses. They also serve as angiogenesis promoting cells by production of pro-angiogenic factors and matrix metalloproteinases (MMPs) and vascular constructing which guarantee supplying oxygen and nutrients to solid tumor cells. Furthermore, TAMs play important functions in tumor metastasis through contributing to invasion, extravasation, survival, intravasation, and colonization of tumor cells. In this review, we summarized macrophage classification, TAMs polarization, and mechanisms underlying TAM-promoting angiogenesis and metastasis.