Viral Vector Mediated Interleukin-10 Gene Transfer in Skin Allograft

Expression of genes with immunoregulatory capacity can potentially decrease rejection of allograft. According to recent studies, viral interleukin (IL)-10 can reduce immune response during allotransplantation and is one of the most promising methods for the prevention of rejection. Our study aimed t...

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Bibliographic Details
Published in:Transplantation proceedings 2020-07, Vol.52 (6), p.1864-1868
Main Authors: Jeong, Yeonjin, Park, Joseph Kyu-Hyung, Eun, Seokchan
Format: Article
Language:English
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Summary:Expression of genes with immunoregulatory capacity can potentially decrease rejection of allograft. According to recent studies, viral interleukin (IL)-10 can reduce immune response during allotransplantation and is one of the most promising methods for the prevention of rejection. Our study aimed to analyze the immunosuppressive potential of recombinant adenovirus-mediated rat IL-10 in rat skin allograft. We performed skin graft surgery 1 hour after infecting the donated skin with adenovirus-mediated rat IL-10. On day 7 postoperatively, the skin allografts were harvested, and acute rejection was graded histologically. Viral IL-10 gene transfer into rat skin allografts improved graft survival and reduced acute rejections. The results of our study suggest that the therapeutic potential of graft viral IL-10 gene transfer is an effective immunosuppressive method for preventing skin allograft rejection. •Immunoregulatory gene expression can potentially decrease rejection of allograft.•IL-10 can reduce immune response during allotransplantation.•Viral IL-10 gene transfer can be an effective method for preventing skin allograft rejection.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2020.02.144