Efficient antibacterial dextran-montmorillonite composite sponge for rapid hemostasis with wound healing

Montmorillonite (MMT) powder, as the most effective hemostats in natural silicates, is restricted for commercial application due to its embolic effect. Until now, it's still a challenge to control the leakage of MMT and avoid its side-effects. Herein, poly aldehyde dextran (PDA)/MMT composite s...

Full description

Saved in:
Bibliographic Details
Published in:International journal of biological macromolecules 2020-10, Vol.160, p.1130-1143
Main Authors: Liu, Chunyu, Liu, Chenyu, Yu, Simiao, Wang, Ning, Yao, Weihe, Liu, Xia, Sun, Guozhen, Song, Qiling, Qiao, Weihong
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial
Bentonite - chemistry
Cell Adhesion
Cell Aggregation
Cells, Cultured
Dextrans - chemistry
Hemostasis
Hemostasis - drug effects
Hemostatics - chemistry
Hemostatics - pharmacology
Rats
Rats, Sprague-Dawley
Wound healing
Wound Healing - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Montmorillonite (MMT) powder, as the most effective hemostats in natural silicates, is restricted for commercial application due to its embolic effect. Until now, it's still a challenge to control the leakage of MMT and avoid its side-effects. Herein, poly aldehyde dextran (PDA)/MMT composite sponge (PM) with commendable tissue adhesion, antibacterial, and wound healing performances is developed for massive hemorrhage control. Based on the high degree of perfect synergism of PDA and MMT, the PM sponge can rapidly seal the wound, and promote cells aggregation and adhesion, whole coagulation system activation, resulting in shortened clotting time from 480 s to
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2020.05.140