The effects of apoptosis and apelin on lymph node metastasis in invasive breast carcinomas

This study aimed to evaluate the biological and clinical significance of apelin-36 in breast cancer and to compare apelin-36 expression and apoptotic index in both breast tissue and metastatic lymph nodes in patients with invasive breast carcinoma. In this study, both tumor tissue and metastatic lym...

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Bibliographic Details
Published in:Clinical and experimental medicine 2020-11, Vol.20 (4), p.507-514
Main Authors: Baran, Munevver, Ozturk, Fıgen, Canoz, Ozlem, Onder, Gozde Ozge, Yay, Arzu
Format: Article
Language:English
Subjects:
Apoptosis
Breast cancer
Breast carcinoma
Correlation analysis
Hematology
Internal Medicine
Invasiveness
Lymph nodes
Lymphatic system
Mastectomy
Medicine
Medicine & Public Health
Metastases
Metastasis
Oncology
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Summary:This study aimed to evaluate the biological and clinical significance of apelin-36 in breast cancer and to compare apelin-36 expression and apoptotic index in both breast tissue and metastatic lymph nodes in patients with invasive breast carcinoma. In this study, both tumor tissue and metastatic lymph nodes of the same patient were collected from 60 cases of invasive breast carcinoma patients (IDC, ILC) and 20 cases of normal breast tissue with no tumor from mammoplasty were used as the control group. The expression of apelin was examined with immunohistochemically, and the apoptotic index was examined with TUNEL methods. According to Kruskal–Wallis analysis, there was a significant difference between IDC and the control group when the apelin expression was compared between the breast tissues ( p  = 0.001). There were significant differences between the three groups when comparing relationships with apoptotic index ( p  
ISSN:1591-8890
1591-9528
DOI:10.1007/s10238-020-00635-2