Severe Rhabdomyolysis in Glucose-6-Phosphate Dehydrogenase Deficiency

Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is an X-linked genetic disorder associated with intravascular hemolysis. Rhabdomyolysis with myoglobinuria in a patient with G6PD deficiency is a very rare manifestation, in fact, to the best of our knowledge, only a few case reports have been publ...

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Bibliographic Details
Published in:The American journal of the medical sciences 2020-07, Vol.360 (1), p.72-74
Main Authors: Singh, Balraj, Kaur, Parminder, Chan, Kok Hoe, Lahita, Robert G., Maroules, Michael, Chandran, Chandra
Format: Article
Language:English
Subjects:
G6PD deficiency
Intravascular hemolysis
Rhabdomyolysis
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Summary:Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is an X-linked genetic disorder associated with intravascular hemolysis. Rhabdomyolysis with myoglobinuria in a patient with G6PD deficiency is a very rare manifestation, in fact, to the best of our knowledge, only a few case reports have been published in the literature to date. Herein, we report an unusual presentation of a 33-year-old male with G6PD deficiency with multiple episodes of severe rhabdomyolysis with no significant concurrent hemolysis. This case supports the hypothesis that rhabdomyolysis may be a rare manifestation of G6PD deficiency, though the exact causation still remains unclear.
ISSN:0002-9629
1538-2990
DOI:10.1016/j.amjms.2020.03.018