Comparison of intravitreal melphalan with and without topotecan in the management of vitreous disease in retinoblastoma

Purpose To evaluate clinical outcomes and enucleation rates after intravitreal melphalan (IVM) alone and after IVM combined with intravitreal topotecan (IVT) for the treatment of vitreous disease, and to a lesser extent subretinal and retrohyaloid seeds, in patients with retinoblastoma. Study design...

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Bibliographic Details
Published in:Japanese journal of ophthalmology 2020-07, Vol.64 (4), p.351-358
Main Authors: Kiratli, Hayyam, Koç, Irem, Öztürk, Ebru, Varan, Ali, Akyüz, Canan
Format: Article
Language:English
Subjects:
Cancer
Clinical Investigation
Cloud seeding
Enucleation
Health services
Injection
Medical treatment
Medicine
Medicine & Public Health
Melphalan
Ophthalmology
Patients
Rank tests
Regression analysis
Retina
Retinoblastoma
Seeds
Side effects
Statistical analysis
Topotecan
Tumors
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Summary:Purpose To evaluate clinical outcomes and enucleation rates after intravitreal melphalan (IVM) alone and after IVM combined with intravitreal topotecan (IVT) for the treatment of vitreous disease, and to a lesser extent subretinal and retrohyaloid seeds, in patients with retinoblastoma. Study design A retrospective analysis of 77 eyes of 72 consecutive patients. Methods Demographic data, classification of tumors, seed type (dust, sphere or cloud) before injection and at the end of follow-up, injection type (IVM or IVM+IVT), doses of IVM and IVT, number of injections, follow-up time, enucleation status and side effects were recorded. Cox regression analysis and log-rank test for Kaplan-Meier curves were performed. Results Of 77 eyes, 40 received IVM alone (group 1) and 37 received IVM+IVT (group 2). Enucleation rates were 62.5% (n=25) in group 1 and 10.8% (n=4) in group 2 (p=0.001). Median eye survival was 23.6 months in group 1 and 25.6 months in group 2. Mantel-Cox test revealed statistically significant differences between Kaplan-Meier curves of group 1 and 2 (p=0.022). Multiple Cox regression analysis showed a significantly elevated enucleation rate associated with: IVM only treatment group (p=0.019) and pre-injection cloud type of seeding (p=0.014). Conclusion The combined use of intravitreal melphalan and topotecan provides significantly better results in terms of avoiding enucleation and vitreal and subretinal seed control.
ISSN:0021-5155
1613-2246
DOI:10.1007/s10384-020-00743-2