Tubulointerstitial Nephritis and Uveitis Syndrome: Characterization of Clinical Features

Purpose: To describe clinical manifestations of patients with tubulointerstitial nephritis and uveitis syndrome (TINU) with a focus on posterior segment findings. Methods: Retrospective chart review. Results: 17 patients were diagnosed with TINU. Ten (59%) were female. Average age at presentation wa...

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Bibliographic Details
Published in:Ocular immunology and inflammation 2021-11, Vol.29 (7-8), p.1312-1317
Main Authors: Koreishi, Anjum F., Zhou, Mei, Goldstein, Debra A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
beta 2-Microglobulin - urine
Child
Female
Glucocorticoids - therapeutic use
Humans
interstitial nephritis
interstitial nephritis and uveitis
Male
Middle Aged
Nephritis, Interstitial - diagnosis
Nephritis, Interstitial - drug therapy
Nephritis, Interstitial - urine
pediatric uveitis
Prednisone - therapeutic use
Retrospective Studies
TINU
tubulointerstitial nephritis
tubulointerstitial nephritis and uveitis
uveitis
Uveitis - diagnosis
Uveitis - drug therapy
Uveitis - urine
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Summary:Purpose: To describe clinical manifestations of patients with tubulointerstitial nephritis and uveitis syndrome (TINU) with a focus on posterior segment findings. Methods: Retrospective chart review. Results: 17 patients were diagnosed with TINU. Ten (59%) were female. Average age at presentation was 19 years (range 7-49). Urine β2-microglobulin was elevated in all tested patients. Six patients (35%) had isolated anterior uveitis. Eleven (65%) had posterior segment findings. Three (18%) had multifocal choroidal lesions, seven (41%) had disc edema, four (24%) had macular edema, three (18%) had choroidal neovascular membranes, two (12%) had retinal vasculitis, one (6%) had disc neovascularization and vitreous hemorrhage, one (6%) had bilateral posterior scleritis. Eleven (65%) required systemic steroid therapy, seven (41%) required immunomodulatory therapy. Conclusions: TINU occurs in all age groups. Posterior segment manifestations are common. Most patients required systemic steroid therapy, with a significant number requiring long-term systemic immunomodulation. Careful fundus examination is required on all patients with TINU.
ISSN:0927-3948
1744-5078
DOI:10.1080/09273948.2020.1736311