Increased Th17 and Th22 Cell Percentages Predict Acute Lung Injury in Patients with Sepsis

Purpose This study was conducted to investigate the percentages of Th22 and Th17 cells in the peripheral blood of septic patients with and without acute lung injury (ALI) and their clinical significance. Methods A total of 479 patients were divided into non-ALI and ALI groups. The percentages of Th2...

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Bibliographic Details
Published in:Lung 2020-08, Vol.198 (4), p.687-693
Main Authors: Li, Gang, Zhang, Liangtian, Han, Nannan, Zhang, Ke, Li, Hengjie
Format: Article
Language:English
Subjects:
Acute Lung Injury
Acute Lung Injury - blood
Acute Lung Injury - diagnosis
Acute Lung Injury - etiology
Acute respiratory distress syndrome
Adult
Analysis
Biomarkers
Blood
Diagnosis
Diagnostic systems
Early Diagnosis
Female
Helper cells
Humans
Infection
Injuries
Interleukin 17
Interleukin 22
Interleukin 6
Interleukin-17 - blood
Interleukin-6 - blood
Interleukins
Interleukins - blood
Logistic Models
Lungs
Lymphocyte Count
Lymphocytes T
Male
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Middle Aged
Multivariate Analysis
Peripheral blood
Pneumology/Respiratory System
Regression analysis
Risk analysis
Risk factors
Sensitivity and Specificity
Sepsis
Sepsis - blood
Sepsis - complications
T-Lymphocyte Subsets
T-Lymphocytes, Helper-Inducer
Th17 Cells
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Summary:Purpose This study was conducted to investigate the percentages of Th22 and Th17 cells in the peripheral blood of septic patients with and without acute lung injury (ALI) and their clinical significance. Methods A total of 479 patients were divided into non-ALI and ALI groups. The percentages of Th22 and Th17 cells and the levels of interleukin 22 (IL-22), 6 (IL-6), and 17 (IL-17) were determined. Receiver operating characteristic curve analysis was performed to assess the diagnostic value of Th22 and Th17 cells to predict sepsis-induced ALI. Results The lung injury prediction score (LIPS), IL-6, IL-17, and IL-22 levels and the percentages of Th17 and Th22 cells were significantly higher in the ALI group ( P  
ISSN:0341-2040
1432-1750
DOI:10.1007/s00408-020-00362-1