From molecules to populations: appreciating and estimating recombination rate variation

Recombination is a central biological process with implications for many areas in the life sciences. Yet we are only beginning to appreciate variation in the recombination rate along the genome and among individuals, populations and species. Spurred by technological advances, we are now able to brin...

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Bibliographic Details
Published in:Nature reviews. Genetics 2020-08, Vol.21 (8), p.476-492
Main Authors: Peñalba, Joshua V., Wolf, Jochen B. W.
Format: Article
Language:English
Subjects:
631/1647/2217
631/208/182
631/337/149
631/80/641/1633
Agriculture
Animal Genetics and Genomics
Animals
Biological Evolution
Biomedical and Life Sciences
Biomedicine
Cancer Research
Chromosome Mapping
Evolution, Molecular
Evolutionary biology
Gametes
Gene Function
Genetic diversity
Genetic recombination
Genetic research
Genetic Testing
Genetic Variation
Genetics, Population
Genomes
Genomics - methods
Human Genetics
Humans
Miosis
Properties
Recombination
Recombination, Genetic
Review Article
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Summary:Recombination is a central biological process with implications for many areas in the life sciences. Yet we are only beginning to appreciate variation in the recombination rate along the genome and among individuals, populations and species. Spurred by technological advances, we are now able to bring variation in this key biological parameter to centre stage. Here, we review the conceptual implications of recombination rate variation and guide the reader through the assumptions, strengths and weaknesses of genomic inference methods, including population-based, pedigree-based and gamete-based approaches. Appreciation of the differences and commonalities of these approaches is a prerequisite to formulate a unifying and comparative framework for understanding the molecular and evolutionary mechanisms shaping, and being shaped by, recombination. Genetic recombination is a fundamental biological process generating genetic variation by shuffling combinations of alleles. In this Review, Peñalba and Wolf focus on how sequencing-based approaches are providing diverse insights into recombination rate variation across levels of biological organization and timescales, from individual gametes of single individuals to populations through evolutionary history.
ISSN:1471-0056
1471-0064
DOI:10.1038/s41576-020-0240-1