Loading…

Passion fruit (Passiflora edulis) leaf aqueous extract ameliorates intestinal epithelial barrier dysfunction and reverts inflammatory parameters in Caco-2 cells monolayer

[Display omitted] •Passiflora edulis leaf aqueous extract (PELE) is a potent source of antioxidants.•PELE reduced inflammation in Caco-2 cells monolayer.•The treatment with PELE was effective in protecting the tight junction barrier function.•PELE may promote a protective effect by repairing the int...

Full description

Saved in:
Bibliographic Details
Published in:Food research international 2020-07, Vol.133, p.109162-109162, Article 109162
Main Authors: Cristina Lopes do Carmo, Mônica, Mateus Martins, Isabela, Elisa Ramos Magalhães, Ana, Roberto Maróstica Júnior, Mário, Alves Macedo, Juliana
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] •Passiflora edulis leaf aqueous extract (PELE) is a potent source of antioxidants.•PELE reduced inflammation in Caco-2 cells monolayer.•The treatment with PELE was effective in protecting the tight junction barrier function.•PELE may promote a protective effect by repairing the intestinal epithelial integrity. The aqueous extract of Passiflora edulis leaves is rich in bioactive polyphenolics, with antioxidant and anti-inflammatory properties. In this study, the recovery of barrier dysfunction and the anti-inflammatory effect of P. edulis leaf aqueous extract (PELE) were evaluated using a Caco-2 monolayer model challenged with IL-1β and LPS. After inflammatory stimuli, it was observed a 28% reduction in transepithelial electrical resistance (TER) and 78% increase of LY permeability. After 48-h treatment with PELE (10 mg mL−1), the monolayer showed 35% increase in TER after inflammatory decreases, and 67% lower LY paracellular permeability, showing a recovery of the monolayer integrity. The treatment also suppressed IL-8 production in 65%. Our results suggest that PELE is a potent source of antioxidants that may promote a protective effect by repairing the intestinal epithelial integrity.
ISSN:0963-9969
1873-7145
DOI:10.1016/j.foodres.2020.109162