Assessment of cows milk‐related symptom scoring awareness tool in young Turkish children

• Published in: Journal of paediatrics and child health 2020-11, Vol.56 (11), p.1799-1805
• Main Authors: Selbuz, Suna Kaymak, Altuntaş, Cansu, Kansu, Aydan, Kırsaçlıoğlu, Ceyda Tuna, Kuloğlu, Zarife, İlarslan, Nisa Eda Çullas, Doğulu, Neslihan, Günay, Fatih, Topçu, Seda, Ulukol, Betül
• Format: Article
• Language: English
• Subjects: Allergens; Animals; Blood diseases; Cattle; Child; Childrens health; CoMiSS; cows milk protein allergy; eosinophilia; Female; Food allergies; Humans; Immunoglobulin E; Infant; Medical diagnosis; Milk; Milk Hypersensitivity - diagnosis; Milk Proteins; Pediatrics; Recurrence
• ISSN: 1034-4810; 1440-1754
• DOI: 10.1111/jpc.14921

Background The diagnosis of cows milk protein allergy (CMPA) is not always easy. Cow's Milk‐related Symptom Score (CoMiSS) has been developed to raise the awareness of CMPA among the primary health‐care providers. In this study, we aimed to evaluate the validity of CoMiSS as a diagnostic approach of CMPA in infants in our country. Methods Infants with a CoMiSS of more than 12 points were included. An elimination diet was implemented in these infants for 4 weeks, and CoMiSS was reapplied. Infants with a reduction of ≥3 points in CoMiSS were considered responsive to the elimination diet, and an open oral challenge test was performed. Infants with symptom recurrence were diagnosed with CMPA. Results The study included 168 infants. When they were included in the study, the first CoMiSS score was 13.6 ± 1.9. After the elimination diet, the number of responsive infants was 154 (91.7%). Of the infants, 91 (54.2%) were diagnosed with CMPA with positive challenge. The majority of the patients diagnosed with CMPA presented with gastrointestinal and/or dermatological symptoms (80.3%). Positive family history of allergy was more prevalent in CMPA(+) infants (P