Assessment of brain volumes obtained from MP-RAGE and MP2RAGE images, quantified using different segmentation methods

Objective For clinical purposes and research projects in neurological disease, it is of interest to evaluate the performance and comparability of available sequences and software packages for brain volume assessment to determine whether they provide equivalent results. This study compares cross-sect...

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Bibliographic Details
Published in:Magma (New York, N.Y.) N.Y.), 2020-12, Vol.33 (6), p.757-767
Main Authors: Alonso, Juli, Pareto, Deborah, Alberich, Manel, Kober, Tobias, Maréchal, Bénédicte, Lladó, Xavier, Rovira, Alex
Format: Article
Language:English
Subjects:
Basic Science - Image analysis
Biomedical Engineering and Bioengineering
Computer Appl. in Life Sciences
Health Informatics
Imaging
Medicine
Medicine & Public Health
Radiology
Research Article
Solid State Physics
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Summary:Objective For clinical purposes and research projects in neurological disease, it is of interest to evaluate the performance and comparability of available sequences and software packages for brain volume assessment to determine whether they provide equivalent results. This study compares cross-sectional brain volume values derived from images obtained with MP-RAGE or MP2RAGE sequences, using SIENA/X, SPM, or MorphoBox. Materials and methods MP-RAGE and MP2RAGE T1-weighted images were obtained from 24 healthy volunteers. Back-to-back scans were performed in 12 of them. Brain volumes, coefficients of variation, and concordance coefficients were determined. Results Significant differences were found for most brain volumes derived from MP-RAGE and MP2RAGE images. MP2RAGE-derived measures showed a non-significant trend to larger coefficients of variation. There were statistical differences between brain volumes determined with the three software packages, whereas coefficients of variation were comparable for most brain volumes. Correlation and concordance values were lower for CSF and brain parenchyma fraction measures. Conclusion The results obtained advise caution when comparing brain volumes obtained by different sequences and software packages. Of note, for most brain volume measures, the MP2RAGE and MorphoBox coefficients of variation were similar to those obtained with MP-RAGE, SIENA/X or SPM, accepted tools for clinical research.
ISSN:0968-5243
1352-8661
DOI:10.1007/s10334-020-00854-4