Thermoplastic microfluidic bioreactors with integrated electrodes to study tumor treating fields on yeast cells

Tumor-treating fields (TTFields) are alternating electrical fields of intermediate frequency and low intensity that can slow or inhibit tumor growth by disrupting mitosis division of cancerous cells through cell cycle proteins. In this work, for the first time, an in-house fabricated cyclo-olefin po...

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Bibliographic Details
Published in:Biomicrofluidics 2020-05, Vol.14 (3), p.034104-034104
Main Authors: Gencturk, Elif, Ulgen, Kutlu O., Mutlu, Senol
Format: Article
Language:English
Subjects:
Bioreactors
Cell cycle
Electrodes
Electroporation
Fluorescence
Microfluidics
Mitosis
Polyolefins
Proteins
Regular
Tumors
Yeast
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Summary:Tumor-treating fields (TTFields) are alternating electrical fields of intermediate frequency and low intensity that can slow or inhibit tumor growth by disrupting mitosis division of cancerous cells through cell cycle proteins. In this work, for the first time, an in-house fabricated cyclo-olefin polymer made microfluidic bioreactors are integrated with Cr/Au interdigitated electrodes to test TTFields on yeast cells with fluorescent protein:Nop56 gene. A small gap between electrodes (50 μm) allows small voltages (
ISSN:1932-1058
1932-1058
DOI:10.1063/5.0008462