Unleash the Association of Mitochondrial Uncoupling Protein (UCP2) Promoter Variant (G-866A; rs659366) with Obesity: Stepping from a Case–Control Study to a Meta-analysis

Numerous eligible articles investigated the potential impact of the promoter region of UCP2 (rs659366) variant and the susceptibility for obesity with questionable outcomes. Our team designed this case–control combined with meta-analysis survey to illustrate the contribution of this variant with obe...

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Bibliographic Details
Published in:Biochemical genetics 2020-10, Vol.58 (5), p.738-770
Main Authors: Abd El Daim, Hamada A., Elsaid, Afaf M., Mousa, Amany A., El-Eshmawy, Mervat M., Lashin, Lashin S., Toraih, Eman A., Elshazli, Rami M.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Case studies
Case-Control Studies
Deoxyribonucleic acid
DNA
Egypt
Female
Human Genetics
Humans
Male
Medical Microbiology
Meta-analysis
Mitochondria
Mitochondrial uncoupling protein 2
Obesity
Obesity - genetics
Original Article
Polls & surveys
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Uncoupling Protein 2 - genetics
Zoology
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Summary:Numerous eligible articles investigated the potential impact of the promoter region of UCP2 (rs659366) variant and the susceptibility for obesity with questionable outcomes. Our team designed this case–control combined with meta-analysis survey to illustrate the contribution of this variant with obesity. This case–control survey was formulated based on 110 obese Egyptian patients and 122 non-obese controls. Genomic DNA was amplified for ascertaining of UCP2 (G-866A; rs659366) variant exploiting the PCR–RFLP technique. A literature search was completed to investigate the involvement of this variant with obesity from various genetic databases. In this case–control study, the distribution of UCP2 (rs659366) variant showed a significant association with obesity among Egyptian subjects under allelic and dominant models ( P value = 0.0006 and 
ISSN:0006-2928
1573-4927
DOI:10.1007/s10528-020-09973-y