Bio-ink for on-demand printing of living cells

Drop-on-demand bioprinting allows the controlled placement of living cells, and will benefit research in the fields of tissue engineering, drug screening and toxicology. We show that a bio-ink based on a novel microgel suspension in a surfactant-containing tissue culture medium can be used to reprod...

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Published in:Biomaterials science 2013-01, Vol.1 (2), p.224-230
Main Authors: Ferris, Cameron J., Gilmore, Kerry J., Beirne, Stephen, McCallum, Donald, Wallace, Gordon G., in het Panhuis, Marc
Format: Article
Language:English
Subjects:
Agglomeration
Printing
Prints
Product innovation
Settling
Surgical implants
Three dimensional printing
Tissue engineering
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creator Ferris, Cameron J.
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Wallace, Gordon G.
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description Drop-on-demand bioprinting allows the controlled placement of living cells, and will benefit research in the fields of tissue engineering, drug screening and toxicology. We show that a bio-ink based on a novel microgel suspension in a surfactant-containing tissue culture medium can be used to reproducibly print several different cell types, from two different commercially available drop-on-demand printing systems, over long printing periods. The bio-ink maintains a stable cell suspension, preventing the settling and aggregation of cells that usually impedes cell printing, whilst meeting the stringent fluid property requirements needed to enable printing even from many-nozzle commercial inkjet print heads. This innovation in printing technology may pave the way for the biofabrication of multi-cellular structures and functional tissue.
doi_str_mv 10.1039/c2bm00114d
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source Royal Society of Chemistry
subjects Agglomeration
Printing
Prints
Product innovation
Settling
Surgical implants
Three dimensional printing
Tissue engineering
title Bio-ink for on-demand printing of living cells
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