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Effect of Surgically Induced Weight Loss on Biomarkers of Endothelial Dysfunction: a Systematic Review and Meta-Analysis
Background This meta-analysis was performed to assess the effects of bariatric surgery (BS) on the selected markers of endothelial dysfunction, including monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin...
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Published in: | Obesity surgery 2020-09, Vol.30 (9), p.3549-3560 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background
This meta-analysis was performed to assess the effects of bariatric surgery (BS) on the selected markers of endothelial dysfunction, including monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin.
Methods
PubMed, Scopus, and Google scholar were systematically searched to identify related studies published from inception to November 2019 to find eligible studies.
Results
A total of 29 different studies were included. BS reduced the concentrations of MCP-1 (weighted mean difference (WMD) = − 58.91; 95%CI (confidence interval), − 77.10 to − 40.72;
P
= ˂ 0.001), ICAM-1 (WMD = − 36.58; 95%CI, − 49.65 to − 23.52;
P
= ˂ 0.001), and E-selectin (WMD = − 11.22; 95%CI, − 14.43 to − 8.01;
P
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ISSN: | 0960-8923 1708-0428 |
DOI: | 10.1007/s11695-020-04710-1 |