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Effect of Surgically Induced Weight Loss on Biomarkers of Endothelial Dysfunction: a Systematic Review and Meta-Analysis

Background This meta-analysis was performed to assess the effects of bariatric surgery (BS) on the selected markers of endothelial dysfunction, including monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin...

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Bibliographic Details
Published in:Obesity surgery 2020-09, Vol.30 (9), p.3549-3560
Main Authors: Seyyedi, Javad, Alizadeh, Shahab
Format: Article
Language:English
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Summary:Background This meta-analysis was performed to assess the effects of bariatric surgery (BS) on the selected markers of endothelial dysfunction, including monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin. Methods PubMed, Scopus, and Google scholar were systematically searched to identify related studies published from inception to November 2019 to find eligible studies. Results A total of 29 different studies were included. BS reduced the concentrations of MCP-1 (weighted mean difference (WMD) = − 58.91; 95%CI (confidence interval), − 77.10 to − 40.72; P  = ˂ 0.001), ICAM-1 (WMD = − 36.58; 95%CI, − 49.65 to − 23.52; P  = ˂ 0.001), and E-selectin (WMD = − 11.22; 95%CI, − 14.43 to − 8.01; P  
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-020-04710-1