Seronegative autoimmune atrophic gastritis is more common in elderly patients

Autoimmune atrophic gastritis (AAG) diagnosis is based on specific histological findings and anti-parietal cell antibodies (PCA) considered the serological hallmark of AAG, although a subgroup of AAG patients may be seronegative. To assess the occurrence and clinical features of seronegative compare...

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Bibliographic Details
Published in:Digestive and liver disease 2020-11, Vol.52 (11), p.1310-1314
Main Authors: Conti, Laura, Lenti, Marco Vincenzo, Di Sabatino, Antonio, Miceli, Emanuela, Galli, Gloria, Cazzato, Maria, Falangone, Francesca, Annibale, Bruno, Lahner, Edith
Format: Article
Language:English
Subjects:
Anti-parietal cell antibodies
Autoimmune atrophic gastritis
Gastric autoimmunity
Pernicious anemia
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Summary:Autoimmune atrophic gastritis (AAG) diagnosis is based on specific histological findings and anti-parietal cell antibodies (PCA) considered the serological hallmark of AAG, although a subgroup of AAG patients may be seronegative. To assess the occurrence and clinical features of seronegative compared to seropositive AAG. This is a cross-sectional study including 516 consecutive adult patients (age 59.6 ± 12.8 years, F:M = 2.2:1) with histologically proven AAG diagnosed in two Italian academic referral centers over the last 10 years. PCA were detected at AAG diagnosis. Variables related to the dependent variable of interest (i.e.PCA-negativity) were assessed by univariate/logistic regression analysis. 109/516 AAG patients were seronegative. The mean age of seronegative AAG patients was significantly higher compared to PCA-positive (65.9 ± 14.1vs57.9 ± 15.1 years; p
ISSN:1590-8658
1878-3562
DOI:10.1016/j.dld.2020.04.015