Kidney dysfunction and short term all-cause mortality after transcatheter aortic valve implantation

• Published in: European journal of internal medicine 2020-11, Vol.81, p.32-37
• Main Authors: Sgura, Fabio Alfredo, Arrotti, Salvatore, Magnavacchi, Paolo, Monopoli, Daniel, Gabbieri, Davide, Banchelli, Federico, Tondi, Stefano, Denegri, Andrea, D'Amico, Roberto, Guiducci, Vincenzo, Vignali, Luigi, Boriani, Giuseppe
• Format: Article
• Language: English
• Subjects: Acute kidney injury; Acute Kidney Injury - etiology; Aged; Aged, 80 and over; aortic stenosis; Aortic Valve - surgery; Aortic Valve Stenosis - surgery; chronic kidney disease; Humans; Kidney; Risk Factors; TAVI; Transcatheter Aortic Valve Replacement - adverse effects; Treatment Outcome
• ISSN: 0953-6205; 1879-0828
• DOI: 10.1016/j.ejim.2020.05.027

•Post-procedural AKI is associated with increased short-term mortality in patients treated with TAVI.•Patients with severe CKD with AKI showed the highest 30-day mortality risk.•Closer monitoring and specific kidney protection therapies are required for AKI prevention after TAVI. Acute kidney injury (AKI) after transcatheter aortic valve implantation (TAVI) has been associated with worse outcomes. However, the impact on outcome of AKI in TAVI-patients is not well established. Inoperable patients with severe aortic stenosis (AS) undergoing TAVI in 2010-2018 were enrolled in this study. AKI and chronic kidney disease (CKD) were defined according to KDIGO guidelines. Patients were divided in two groups according to post-procedural AKI development. The primary endpoint was 30-day all-cause mortality across the two groups. A total of 373 patients (mean age 82.3 ± 6) were analyzed. Compared to non-AKI patients, those who developed AKI, were treated more frequently with trans-apical TAVI (66% vs 35%, p