Thiol/disulfide homeostasis in patients with ocular-active and ocular-inactive Behçet disease

Purpose To evaluate thiol/disulfide homeostasis in ocular-active (OA) and ocular-inactive (OI) Behçet disease (BD) patients and compare the data with healthy subjects. Methods Twenty OABD patients, 20 OIBD patients and 20 healthy control subjects were included into the study. The BD ocular attack sc...

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Bibliographic Details
Published in:International ophthalmology 2020-10, Vol.40 (10), p.2643-2650
Main Authors: Balbaba, Mehmet, Ulaş, Fatih, Yıldırım, Hakan, Soydan, Adem, Dal, Ali, Aydın, Süleyman
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Ophthalmology
Original Paper
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Summary:Purpose To evaluate thiol/disulfide homeostasis in ocular-active (OA) and ocular-inactive (OI) Behçet disease (BD) patients and compare the data with healthy subjects. Methods Twenty OABD patients, 20 OIBD patients and 20 healthy control subjects were included into the study. The BD ocular attack score 24 (BOS24) scoring system was used to assess the activity of disease in ocular BD patients. Systemic activity was also evaluated using BD current activity form (BDCAF). The native thiol (NT), total thiol (TT) and disulfide levels and NT/TT, disulfide/NT and disulfide/TT ratios were measured via using an innovative and automated method. Results BOS24 and BDCAF scores were 13.25 ± 2.32 and 4.18 ± 2.06 in OABD patients and 0.31 ± 0.47 and 2.14 ± 1.98 in OIBD patients, respectively. The NT, TT levels and NT/TT ratio were significantly reduced; in contrast, the disulfide levels, disulfide/NT and disulfide/TT ratios were significantly increased in OABD and OIBD patients compared to the healthy control subjects ( p  
ISSN:0165-5701
1573-2630
DOI:10.1007/s10792-020-01445-x