Relationship Between Ablation Lesion Size Estimated by Ablation Index and Different Ablation Settings—an Ex Vivo Porcine Heart Study

• Published in: Journal of cardiovascular translational research 2020-12, Vol.13 (6), p.965-969
• Main Authors: Huang, Shu-Tao, Dong, Jian-Zeng, Du, Xin, Wu, Jia-Hui, Yu, Rong-Hui, Long, De-Yong, Ning, Man, Sang, Cai-Hua, Jiang, Chen-Xi, Bai, Rong, Wen, Song-Nan, Liu, Nian, Li, Song-Nan, Wang, Wei, Guo, Xue-Yuan, Zhao, Xin, Chen, Xuan, Cui, Yi-Kai, Tang, Ri-Bo, Ma, Chang-Sheng
• Format: Article
• Language: English
• Subjects: Animals; Biomedical Engineering and Bioengineering; Biomedicine; Cardiology; Catheter Ablation; Electric Impedance; Glucose - chemistry; Heart Ventricles - pathology; Heart Ventricles - surgery; Human Genetics; Medicine; Medicine & Public Health; Original Article; Saline Solution - chemistry; Sus scrofa; Temperature; Therapeutic Irrigation
• ISSN: 1937-5387; 1937-5395
• DOI: 10.1007/s12265-020-10037-0

This study aimed to verify the reliability of ablation index (AI) for ablation lesion estimating with different settings for radiofrequency (RF) parameters: power, impedance, contact angles, irrigation rate, temperature of irrigation saline, and irrigation solution. RF ablations ( N  = 66) were performed on ex vivo porcine left ventricle submerged in 37 °C saline. The aforementioned ablation parameters were changed to measure whether the size of the ablation lesion was consistent at a fixed AI value of 500. The maximum lesion diameter ( r  = − 0.631, P  = 0.028), depth ( r  = − 0.896, P