Comparison of the efficacy of accelerated corneal cross-linking therapy in different pediatric age groups having progressive keratoconus

Purpose To report a comparison analysis of accelerated corneal cross-linking (A-CXL) treatment for progressive keratoconus patients in different pediatric age groups. Study design Retrospective, cross-sectional. Methods Patients with progressive keratoconus aged ≤ 18 were retrospectively reviewed. F...

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Published in:International ophthalmology 2020-10, Vol.40 (10), p.2651-2658
Main Authors: Ozer, Muhammet Derda, Batur, Muhammed, Mesen, Selma, Tekın, Serek, Seven, Erbil, Yasar, Tekin
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Ophthalmology
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container_title International ophthalmology
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creator Ozer, Muhammet Derda
Batur, Muhammed
Mesen, Selma
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Seven, Erbil
Yasar, Tekin
description Purpose To report a comparison analysis of accelerated corneal cross-linking (A-CXL) treatment for progressive keratoconus patients in different pediatric age groups. Study design Retrospective, cross-sectional. Methods Patients with progressive keratoconus aged ≤ 18 were retrospectively reviewed. Forty-one eyes of 41 patients were included in the study. Patients were divided into two groups according to their age (≤ 14 years and 15–18 years). All patients underwent epithelium-off A-CXL protocol. Acquired data were compared between the two groups. Results The mean age was 14.3 ± 1.8 (10–18) years. Twenty-five (61%) of the participants were male, and 16 (39%) were female. Twenty (49%) patients were separated into group 1 (≤ 14 years of age), and 21 (51%) were in group 2 (15–18 years). Age at presentation was found to be the only factor in anticipating the progression of keratoconus at the second postoperative year visit ( p  
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Study design Retrospective, cross-sectional. Methods Patients with progressive keratoconus aged ≤ 18 were retrospectively reviewed. Forty-one eyes of 41 patients were included in the study. Patients were divided into two groups according to their age (≤ 14 years and 15–18 years). All patients underwent epithelium-off A-CXL protocol. Acquired data were compared between the two groups. Results The mean age was 14.3 ± 1.8 (10–18) years. Twenty-five (61%) of the participants were male, and 16 (39%) were female. Twenty (49%) patients were separated into group 1 (≤ 14 years of age), and 21 (51%) were in group 2 (15–18 years). Age at presentation was found to be the only factor in anticipating the progression of keratoconus at the second postoperative year visit ( p  &lt; 0.001). Progression in keratometric values was detected in seven (35%) of the 20 eyes in group 1, and one (4%) of the 21 patients in group 2 ( Z  = − 2.44, p  = 0.014). Conclusion Even if proper treatment is applied, the progression of keratoconus is likely in patients younger than 14 years of age. Instead of evaluating pediatric patients as a whole, closer follow-up and early treatment may be useful in younger age groups (≤ 14 years).</description><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-020-01446-w</identifier><identifier>PMID: 32488590</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Medicine ; Medicine &amp; Public Health ; Ophthalmology ; Original Paper</subject><ispartof>International ophthalmology, 2020-10, Vol.40 (10), p.2651-2658</ispartof><rights>Springer Nature B.V. 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-aeffaa4a4383d8563be7f3c4cd884122c7286907bc38bb4ba46a1ada4aad6f1a3</citedby><cites>FETCH-LOGICAL-c347t-aeffaa4a4383d8563be7f3c4cd884122c7286907bc38bb4ba46a1ada4aad6f1a3</cites><orcidid>0000-0002-3954-270X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32488590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozer, Muhammet Derda</creatorcontrib><creatorcontrib>Batur, Muhammed</creatorcontrib><creatorcontrib>Mesen, Selma</creatorcontrib><creatorcontrib>Tekın, Serek</creatorcontrib><creatorcontrib>Seven, Erbil</creatorcontrib><creatorcontrib>Yasar, Tekin</creatorcontrib><title>Comparison of the efficacy of accelerated corneal cross-linking therapy in different pediatric age groups having progressive keratoconus</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose To report a comparison analysis of accelerated corneal cross-linking (A-CXL) treatment for progressive keratoconus patients in different pediatric age groups. Study design Retrospective, cross-sectional. Methods Patients with progressive keratoconus aged ≤ 18 were retrospectively reviewed. Forty-one eyes of 41 patients were included in the study. Patients were divided into two groups according to their age (≤ 14 years and 15–18 years). All patients underwent epithelium-off A-CXL protocol. Acquired data were compared between the two groups. Results The mean age was 14.3 ± 1.8 (10–18) years. Twenty-five (61%) of the participants were male, and 16 (39%) were female. Twenty (49%) patients were separated into group 1 (≤ 14 years of age), and 21 (51%) were in group 2 (15–18 years). Age at presentation was found to be the only factor in anticipating the progression of keratoconus at the second postoperative year visit ( p  &lt; 0.001). Progression in keratometric values was detected in seven (35%) of the 20 eyes in group 1, and one (4%) of the 21 patients in group 2 ( Z  = − 2.44, p  = 0.014). Conclusion Even if proper treatment is applied, the progression of keratoconus is likely in patients younger than 14 years of age. 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Study design Retrospective, cross-sectional. Methods Patients with progressive keratoconus aged ≤ 18 were retrospectively reviewed. Forty-one eyes of 41 patients were included in the study. Patients were divided into two groups according to their age (≤ 14 years and 15–18 years). All patients underwent epithelium-off A-CXL protocol. Acquired data were compared between the two groups. Results The mean age was 14.3 ± 1.8 (10–18) years. Twenty-five (61%) of the participants were male, and 16 (39%) were female. Twenty (49%) patients were separated into group 1 (≤ 14 years of age), and 21 (51%) were in group 2 (15–18 years). Age at presentation was found to be the only factor in anticipating the progression of keratoconus at the second postoperative year visit ( p  &lt; 0.001). Progression in keratometric values was detected in seven (35%) of the 20 eyes in group 1, and one (4%) of the 21 patients in group 2 ( Z  = − 2.44, p  = 0.014). Conclusion Even if proper treatment is applied, the progression of keratoconus is likely in patients younger than 14 years of age. Instead of evaluating pediatric patients as a whole, closer follow-up and early treatment may be useful in younger age groups (≤ 14 years).</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>32488590</pmid><doi>10.1007/s10792-020-01446-w</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3954-270X</orcidid></addata></record>
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Ophthalmology
Original Paper
title Comparison of the efficacy of accelerated corneal cross-linking therapy in different pediatric age groups having progressive keratoconus
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