Biological applications study of bio‐nanocomposites based on chitosan/TiO2 nanoparticles polymeric films modified by oleic acid

The aim of the present study was to prepare and characterize nanocomposite films to improve the treatment of skin wounds by applying the film as a bandage. To modify chitosan (Cs) and to prepare nanocomposites, a mixture between titanium dioxide nanoparticles (TiO2NPs) was performed at different con...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2021-02, Vol.109 (2), p.232-247
Main Authors: Hanafy, Magda S., Desoky, Waled M., Hussein, Elham M., El‐Shaer, Nahla H., Gomaa, Mohamed, Gamal, Amira A., Esawy, Mona A., Guirguis, Osiris W.
Format: Article
Language:English
Subjects:
Animal models
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Bacteria
Biodegradation
Chitosan
chitosan and oleic acid
chitosan and titanium dioxide nanoparticles
Emission analysis
Field emission microscopy
Fourier analysis
Fourier transforms
Gram-negative bacteria
High resolution electron microscopy
Infrared analysis
Infrared spectroscopy
Mechanical properties
Microorganisms
Microscopy
Nanocomposites
nanocomposites films
Nanoparticles
Oleic acid
Polymer films
Scanning electron microscopy
Thermal analysis
Thin films
Titanium dioxide
Water absorption
Wound healing
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Summary:The aim of the present study was to prepare and characterize nanocomposite films to improve the treatment of skin wounds by applying the film as a bandage. To modify chitosan (Cs) and to prepare nanocomposites, a mixture between titanium dioxide nanoparticles (TiO2NPs) was performed at different concentrations (2, 5, 10 and 15 wt%) and oleic acid (OA). The thin nanocomposite films were prepared by using casting method. The prepared films (Cs, Cs/TiO2NPs, Cs/OA and Cs/OA/TiO2NPs) were described by water absorption (swelling study) and biological degradation. Physico‐chemical characterizations of Cs, Cs/OA, Cs/TiO2NPs and Cs/OA/TiO2NPs (with only 15 wt% TiO2NPs) films were determined by X‐ray diffraction, transmission high‐resolution electron microscopy, field emission scanning electron microscopy, thermal analysis and Fourier transform infrared spectroscopy as well as their mechanical properties. Antimicrobial activity against microorganisms has been studied to assess activity against bacteria. The prepared nanocomposite films showed good antimicrobial activity for both Gram‐positive and Gram‐negative bacteria. The therapeutic effects of Cs‐TiO2NPs‐oleic acid nanocomposites on healing excision wounds were studied in rat animal model. The data obtained revealed that groups treated with nanocomposites showed enhancement wound closure and speed up wound healing time.
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.37019