Cobbling Together the Myddosome

An organism’s ability to recognize and respond quickly and appropriately to pathogenic stimuli is a fundamental aspect of innate immunity. Harnessing the dynamic nature of fluorescent microscopy and the resolution of cryo-electron microscopy, Moncrieffe et al. (2020) characterize MyD88-only filament...

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Bibliographic Details
Published in:Structure (London) 2020-06, Vol.28 (6), p.598-600
Main Authors: Snyder, Michelle L.D., Snyder, Greg A.
Format: Article
Language:English
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Summary:An organism’s ability to recognize and respond quickly and appropriately to pathogenic stimuli is a fundamental aspect of innate immunity. Harnessing the dynamic nature of fluorescent microscopy and the resolution of cryo-electron microscopy, Moncrieffe et al. (2020) characterize MyD88-only filaments and provide insight into the mechanisms underlying innate immune signaling. An organism’s ability to recognize and respond quickly and appropriately to pathogenic stimuli is a fundamental aspect of innate immunity. Harnessing the dynamic nature of fluorescent microscopy and the resolution of cryo-electron microscopy, Moncrieffe et al. (2020) characterize MyD88-only filaments and provide insight into the mechanisms underlying innate immune signaling.
ISSN:0969-2126
1878-4186
DOI:10.1016/j.str.2020.05.006