Nitric oxide and TNF-α are correlates of diabetic retinopathy independent of hs-CRP and HbA1c

Purpose Regarding the role of inflammation in progression of diabetes this study was conducted to investigate the association between inflammatory biomarkers such as nitric oxide (NO), tumor necrosis factor alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) with the chance of existence...

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Bibliographic Details
Published in:Endocrine 2020-09, Vol.69 (3), p.536-541
Main Authors: Khaloo, Pegah, Qahremani, Reihane, Rabizadeh, Soghra, Omidi, Mohammad, Rajab, Armin, Heidari, Firouzeh, Farahmand, Ghasem, Bitaraf, Masoume, Mirmiranpour, Hossein, Esteghamati, Alireza, Nakhjavani, Manouchehr
Format: Article
Language:English
Subjects:
Biomarkers
C-reactive protein
Cholesterol
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetic retinopathy
Endocrinology
Glucose
Hemoglobin
High density lipoprotein
Humanities and Social Sciences
Inflammation
Internal Medicine
Low density lipoprotein
Medicine
Medicine & Public Health
multidisciplinary
Nitric oxide
Original Article
Retinopathy
Science
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Summary:Purpose Regarding the role of inflammation in progression of diabetes this study was conducted to investigate the association between inflammatory biomarkers such as nitric oxide (NO), tumor necrosis factor alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) with the chance of existence of diabetic retinopathy and its progression in patients with diabetes. Methods A total of 83 patients with T2DM (Type 2 diabetes mellitus) were divided into three groups of patients with proliferative diabetic retinopathy (PDR), patients with non-proliferative diabetic retinopathy (NPDR) and patients without diabetic retinopathy (NDR) based on ophthalmologic funduscopic examination. Twenty six healthy controls were also enrolled. Blood samples were taken after 12 h of overnight fasting, NO, TNF-α, and hs-CRP were measured. Association of the level of these biomarkers with retinopathy was analyzed. Results The levels of TNF-α, NO and hs-CRP were higher among patients with diabetic retinopathy. Multinomial Logistic Regression model showed that TNF-α and NO could predict the presence of retinopathy among patients with diabetes when adjusted for hs-CRP, HbA1c, FBS, gender, total cholesterol, triglyceride, HDL, LDL, BMI, and age (respectively OR = 1.76, CI 95% = 1.01–3.02, p  = 0.046 and OR = 1.12, CI 95% = 1.05–1.18, p  
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-020-02353-x