Endovascular recanalization for symptomatic subacute and chronically occluded internal carotid artery: feasibility, safety, a modified radiographic classification system, and clinical outcomes

• Published in: Neuroradiology 2020-10, Vol.62 (10), p.1323-1334
• Main Authors: Mo, Liumei, Ma, Guixian, Dai, Chengbo, Wang, Shuo, Li, Changmao, Ma, Tengyun, Yang, Zhexian, He, Chizhong, Xiao, Hao, Wang, Lijuan, Duan, Jinhai, Zhang, Yuhu
• Format: Article
• Language: English
• Subjects: Angiography; Asymptomatic; Cardiovascular system; Carotid arteries; Carotid artery; Cerebral blood flow; Cerebral infarction; Classification; Clinical outcomes; Complications; Feasibility studies; Health services; Imaging; Infarction; Interventional Neuroradiology; Ischemia; Medical imaging; Medicine; Medicine & Public Health; Neurological complications; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Occlusion; Patients; Radiology; Safety
• ISSN: 0028-3940; 1432-1920
• DOI: 10.1007/s00234-020-02458-0

Purpose To evaluate the feasibility and safety of endovascular recanalization for symptomatic subacute and chronic internal carotid artery occlusion (ICAO); to propose a newly modified radiographic classification of ICAO that can rigorously identify suitable candidates for endovascular ICAO treatment. Methods We included 42 consecutive patients who had ICAO with ischaemic symptoms refractory to medical therapy. We examined the symptomatology, complications, follow-up results and radiographic images of ICAO receiving attempted endovascular treatment. We attempted to stratify all radiographic images into categories based on morphological occlusion patterns, occlusion segments and distal ICA reconstitution on digital subtraction angiography (DSA). Results Four types (A–D) of radiographic ICAO were identified. We redefined type B as having a tapered stump but no distal lumen. The rate of successful recanalization was 83.33% (35/42 ICAOs; type A, 18/20; type B, 7/10; type C, 10/11; type D, 0/1). The perioperative complication rate was 11.90% (5/42), including 3 asymptomatic distal embolisms, 1 symptomatic cerebral infarction and 1 asymptomatic carotid artery dissection. None of these technique-related complications led to severe neurological damage or death. Modified Rankin Scale (mRS) scores after 1–20 months of follow-up were significantly decreased in successfully revascularized patients ( P < 0.001). There was no significant change in mRS scores in the 7 patients in whom recanalization failed ( P > 0.05). Conclusions Endovascular recanalization seems to achieve technical success and clinical improvement for symptomatic subacute and chronic ICAO. Additionally, our newly modified radiographic classification of ICAO may be valuable in assessing the technical feasibility and safety of procedures in symptomatic ICAO patients.