Signal quality and patient experience with wearable devices for epilepsy management

• Published in: Epilepsia (Copenhagen) 2020-11, Vol.61 (S1), p.S25-S35
• Main Authors: Nasseri, Mona, Nurse, Ewan, Glasstetter, Martin, Böttcher, Sebastian, Gregg, Nicholas M., Laks Nandakumar, Aiswarya, Joseph, Boney, Pal Attia, Tal, Viana, Pedro F., Bruno, Elisa, Biondi, Andrea, Cook, Mark, Worrell, Gregory A., Schulze‐Bonhage, Andreas, Dümpelmann, Matthias, Freestone, Dean R., Richardson, Mark P., Brinkmann, Benjamin H.
• Format: Article
• Language: English
• Subjects: Accelerometry - instrumentation; Adult; Aged; Automation; Biosensors; EEG; Entropy; Epilepsy; Female; Galvanic Skin Response - physiology; Humans; Learning algorithms; Machine learning; Male; Middle Aged; Monitoring, Ambulatory - instrumentation; Noise; patient experience; Patient Preference; Photoplethysmography - instrumentation; Signal Processing, Computer-Assisted; signal quality; Wearable computers; wearable devices; Wearable Electronic Devices; Wrist; Young Adult
• ISSN: 0013-9580; 1528-1167
• DOI: 10.1111/epi.16527

Noninvasive wearable devices have great potential to aid the management of epilepsy, but these devices must have robust signal quality, and patients must be willing to wear them for long periods of time. Automated machine learning classification of wearable biosensor signals requires quantitative measures of signal quality to automatically reject poor‐quality or corrupt data segments. In this study, commercially available wearable sensors were placed on patients with epilepsy undergoing in‐hospital or in‐home electroencephalographic (EEG) monitoring, and healthy volunteers. Empatica E4 and Biovotion Everion were used to record accelerometry (ACC), photoplethysmography (PPG), and electrodermal activity (EDA). Byteflies Sensor Dots were used to record ACC and PPG, the Activinsights GENEActiv watch to record ACC, and Epitel Epilog to record EEG data. PPG and EDA signals were recorded for multiple days, then epochs of high‐quality, marginal‐quality, or poor‐quality data were visually identified by reviewers, and reviewer annotations were compared to automated signal quality measures. For ACC, the ratio of spectral power from 0.8 to 5 Hz to broadband power was used to separate good‐quality signals from noise. For EDA, the rate of amplitude change and prevalence of sharp peaks significantly differentiated between good‐quality data and noise. Spectral entropy was used to assess PPG and showed significant differences between good‐, marginal‐, and poor‐quality signals. EEG data were evaluated using methods to identify a spectral noise cutoff frequency. Patients were asked to rate the usability and comfort of each device in several categories. Patients showed a significant preference for the wrist‐worn devices, and the Empatica E4 device was preferred most often. Current wearable devices can provide high‐quality data and are acceptable for routine use, but continued development is needed to improve data quality, consistency, and management, as well as acceptability to patients.