Neutralizing BDNF and FGF2 injection into denervated skeletal muscle improve recovery after nerve repair

Background After facial nerve injury and surgical repair in rats, recovery of vibrissal whisking is associated with a high proportion of mono‐innervated neuro‐muscular junctions (NMJs). Our earlier work with Sprague Dawley (SD)/Royal College of Surgeons (RCS) rats, which are blind and spontaneously...

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Published in:Muscle & nerve 2020-09, Vol.62 (3), p.404-412
Main Authors: Rink, Svenja, Chatziparaskeva, Christina, Elles, Luisa, Pavlov, Stoyan, Nohroudi, Klaus, Bendella, Habib, Sarikcioglu, Levent, Manthou, Marilena, Dunlop, Sarah, Gordon, Tessa, Angelov, Doychin N.
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Language:English
Subjects:
axotomy
BDNF
Brain-derived neurotrophic factor
Facial nerve
FGF2
Fibroblast growth factor 2
functional recovery
Growth factors
Injuries
motoneuron
motor endplates
Muscles
Neuromuscular junctions
Peripheral nerves
polyinnervation
Recovery
Recovery (Medical)
Recovery of function
Reinnervation
Restoration
Skeletal muscle
Trophic factors
Vibrissae
vibrissae whisking
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cited_by cdi_FETCH-LOGICAL-c2451-51d53e97062ce432164524b1346ca3492ce658238110b4421de5302aae6335cb3
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container_issue 3
container_start_page 404
container_title Muscle & nerve
container_volume 62
creator Rink, Svenja
Chatziparaskeva, Christina
Elles, Luisa
Pavlov, Stoyan
Nohroudi, Klaus
Bendella, Habib
Sarikcioglu, Levent
Manthou, Marilena
Dunlop, Sarah
Gordon, Tessa
Angelov, Doychin N.
description Background After facial nerve injury and surgical repair in rats, recovery of vibrissal whisking is associated with a high proportion of mono‐innervated neuro‐muscular junctions (NMJs). Our earlier work with Sprague Dawley (SD)/Royal College of Surgeons (RCS) rats, which are blind and spontaneously restore NMJ‐monoinnervation and whisking, showed correlations between functional recovery and increase of fibroblast growth factor‐2 (FGF2) and brain‐derived neurotrophic factor (BDNF) in denervated vibrissal muscles. Methods We used normally sighted rats (Wistar), in which NMJ‐polyinnervation is highly correlated with poor whisking recovery, and injected the vibrissal muscle levator labii superioris (LLS) with combinations of BDNF, anti‐BDNF, and FGF2 at different postoperative periods after facial nerve injury. Results Rats receiving anti‐BDNF+FGF2 showed low NMJ‐polyinnervation and best recovery of whisking amplitude. Conclusions Restoration of target reinnervation after peripheral nerve injury requires a complex mixture of trophic factors with a specific time course of availability for each of them.
doi_str_mv 10.1002/mus.26991
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Our earlier work with Sprague Dawley (SD)/Royal College of Surgeons (RCS) rats, which are blind and spontaneously restore NMJ‐monoinnervation and whisking, showed correlations between functional recovery and increase of fibroblast growth factor‐2 (FGF2) and brain‐derived neurotrophic factor (BDNF) in denervated vibrissal muscles. Methods We used normally sighted rats (Wistar), in which NMJ‐polyinnervation is highly correlated with poor whisking recovery, and injected the vibrissal muscle levator labii superioris (LLS) with combinations of BDNF, anti‐BDNF, and FGF2 at different postoperative periods after facial nerve injury. Results Rats receiving anti‐BDNF+FGF2 showed low NMJ‐polyinnervation and best recovery of whisking amplitude. Conclusions Restoration of target reinnervation after peripheral nerve injury requires a complex mixture of trophic factors with a specific time course of availability for each of them.</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.26991</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley &amp; Sons, Inc</publisher><subject>axotomy ; BDNF ; Brain-derived neurotrophic factor ; Facial nerve ; FGF2 ; Fibroblast growth factor 2 ; functional recovery ; Growth factors ; Injuries ; motoneuron ; motor endplates ; Muscles ; Neuromuscular junctions ; Peripheral nerves ; polyinnervation ; Recovery ; Recovery (Medical) ; Recovery of function ; Reinnervation ; Restoration ; Skeletal muscle ; Trophic factors ; Vibrissae ; vibrissae whisking</subject><ispartof>Muscle &amp; nerve, 2020-09, Vol.62 (3), p.404-412</ispartof><rights>2020 Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals, LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2451-51d53e97062ce432164524b1346ca3492ce658238110b4421de5302aae6335cb3</citedby><cites>FETCH-LOGICAL-c2451-51d53e97062ce432164524b1346ca3492ce658238110b4421de5302aae6335cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail></links><search><creatorcontrib>Rink, Svenja</creatorcontrib><creatorcontrib>Chatziparaskeva, Christina</creatorcontrib><creatorcontrib>Elles, Luisa</creatorcontrib><creatorcontrib>Pavlov, Stoyan</creatorcontrib><creatorcontrib>Nohroudi, Klaus</creatorcontrib><creatorcontrib>Bendella, Habib</creatorcontrib><creatorcontrib>Sarikcioglu, Levent</creatorcontrib><creatorcontrib>Manthou, Marilena</creatorcontrib><creatorcontrib>Dunlop, Sarah</creatorcontrib><creatorcontrib>Gordon, Tessa</creatorcontrib><creatorcontrib>Angelov, Doychin N.</creatorcontrib><title>Neutralizing BDNF and FGF2 injection into denervated skeletal muscle improve recovery after nerve repair</title><title>Muscle &amp; nerve</title><description>Background After facial nerve injury and surgical repair in rats, recovery of vibrissal whisking is associated with a high proportion of mono‐innervated neuro‐muscular junctions (NMJs). Our earlier work with Sprague Dawley (SD)/Royal College of Surgeons (RCS) rats, which are blind and spontaneously restore NMJ‐monoinnervation and whisking, showed correlations between functional recovery and increase of fibroblast growth factor‐2 (FGF2) and brain‐derived neurotrophic factor (BDNF) in denervated vibrissal muscles. Methods We used normally sighted rats (Wistar), in which NMJ‐polyinnervation is highly correlated with poor whisking recovery, and injected the vibrissal muscle levator labii superioris (LLS) with combinations of BDNF, anti‐BDNF, and FGF2 at different postoperative periods after facial nerve injury. Results Rats receiving anti‐BDNF+FGF2 showed low NMJ‐polyinnervation and best recovery of whisking amplitude. Conclusions Restoration of target reinnervation after peripheral nerve injury requires a complex mixture of trophic factors with a specific time course of availability for each of them.</description><subject>axotomy</subject><subject>BDNF</subject><subject>Brain-derived neurotrophic factor</subject><subject>Facial nerve</subject><subject>FGF2</subject><subject>Fibroblast growth factor 2</subject><subject>functional recovery</subject><subject>Growth factors</subject><subject>Injuries</subject><subject>motoneuron</subject><subject>motor endplates</subject><subject>Muscles</subject><subject>Neuromuscular junctions</subject><subject>Peripheral nerves</subject><subject>polyinnervation</subject><subject>Recovery</subject><subject>Recovery (Medical)</subject><subject>Recovery of function</subject><subject>Reinnervation</subject><subject>Restoration</subject><subject>Skeletal muscle</subject><subject>Trophic factors</subject><subject>Vibrissae</subject><subject>vibrissae whisking</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp10EtLAzEQAOAgCtbqwX8Q8KKHbTN5dfeo1apQ9aCCtyXNTjV1HzXZVeqvN0s9CZ5mGL55MIQcAxsBY3xcdWHEdZbBDhkAyyaJVFm6SwYMZJpokb3sk4MQVowxSPVkQN7usWu9Kd23q1_pxeX9jJq6oLPrGaeuXqFtXVPHrG1ogTX6T9NiQcM7ltiaksZ1tkTqqrVvPpF6tDH4DTXLFj3tfV9cG-cPyd7SlAGPfuOQPM-unqY3yfzh-nZ6Pk8slwoSBYUSmE2Y5hal4KCl4nIBQmprhMxiVauUixSALaTkUKASjBuDWghlF2JITrdz40UfHYY2r1ywWJamxqYLOZfAhAKdQaQnf-iq6Xwdr4tKSM5lqnlUZ1tlfROCx2W-9q4yfpMDy_uf51U_tv95tOOt_XIlbv6H-d3z47bjB8xUgd8</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Rink, Svenja</creator><creator>Chatziparaskeva, Christina</creator><creator>Elles, Luisa</creator><creator>Pavlov, Stoyan</creator><creator>Nohroudi, Klaus</creator><creator>Bendella, Habib</creator><creator>Sarikcioglu, Levent</creator><creator>Manthou, Marilena</creator><creator>Dunlop, Sarah</creator><creator>Gordon, Tessa</creator><creator>Angelov, Doychin N.</creator><general>John Wiley &amp; 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subjects axotomy
BDNF
Brain-derived neurotrophic factor
Facial nerve
FGF2
Fibroblast growth factor 2
functional recovery
Growth factors
Injuries
motoneuron
motor endplates
Muscles
Neuromuscular junctions
Peripheral nerves
polyinnervation
Recovery
Recovery (Medical)
Recovery of function
Reinnervation
Restoration
Skeletal muscle
Trophic factors
Vibrissae
vibrissae whisking
title Neutralizing BDNF and FGF2 injection into denervated skeletal muscle improve recovery after nerve repair
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