Clinical feasibility of resting full-cycle ratio as a unique non-hyperemic index of invasive functional lesion assessment

The resting full-cycle ratio (RFR) is a new physiologic index to assess myocardial ischemia. RFR and fractional flow reserve (FFR), the conventionally used index, have not been directly compared in evaluating the entire cardiac cycle. Accordingly, we aimed to compare the diagnostic performance of RF...

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Bibliographic Details
Published in:Heart and vessels 2020-11, Vol.35 (11), p.1518-1526
Main Authors: Ohashi, Hirofumi, Takashima, Hiroaki, Ando, Hirohiko, Suzuki, Akihiro, Sakurai, Shinichiro, Nakano, Yusuke, Sawada, Hiroaki, Fujimoto, Masanobu, Suzuki, Wataru, Shimoda, Masahiro, Tajima, Atomu, Waseda, Katsuhisa, Ohashi, Wataru, Amano, Tetsuya
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomedical Engineering and Bioengineering
Cardiac Catheterization
Cardiac Surgery
Cardiology
Coronary artery
Coronary Artery Disease - diagnosis
Coronary Artery Disease - physiopathology
Coronary Circulation
Coronary Stenosis - diagnostic imaging
Coronary Stenosis - physiopathology
Cycle ratio
Diagnostic systems
Diastole
Feasibility
Feasibility Studies
Female
Fractional Flow Reserve, Myocardial
Heart
Humans
Hyperemia - physiopathology
Ischemia
Lesions
Male
Medicine
Medicine & Public Health
Middle Aged
Myocardial ischemia
Original Article
Predictive Value of Tests
Prognosis
Prospective Studies
Reproducibility of Results
Severity of Illness Index
Systole
Vascular Surgery
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Summary:The resting full-cycle ratio (RFR) is a new physiologic index to assess myocardial ischemia. RFR and fractional flow reserve (FFR), the conventionally used index, have not been directly compared in evaluating the entire cardiac cycle. Accordingly, we aimed to compare the diagnostic performance of RFR directly with FFR and clarify the clinical feasibility of RFR as a unique non-hyperemic index in evaluating the cardiac cycle. The diagnostic performance of RFR was compared with FFR using an automated online calculation software. A total of 156 consecutive patients with 220 intermediate lesions were enrolled. RFR showed significant correlation with FFR ( r  = 0.774, p  
ISSN:0910-8327
1615-2573
DOI:10.1007/s00380-020-01638-5